代谢手术前后患者肝肾功能和血脂水平变化
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

基金项目:

国家临床重点专科;江苏省实验诊断学重点实验室(ZDXKB2016005)


Changes of liver and kidney function and lipid indexes in patients before and after metabolic surgery
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的:探讨肥胖患者代谢手术(metabolic surgery,MS)后1年内血清肝肾功能指标和血脂水平的变化。方法:对南京医科大学第一附属医院119例实行MS的患者进行回顾性分析。采集患者术前、术后即刻及1、3、6、12个月静脉血,分别进行血清肝肾功能指标和血脂水平检测。结果:术前血清丙氨酸氨基转移酶(alanine transaminase,ALT)、天门冬氨酸氨基转移酶(aspartate aminotransferase,AST)、碱性磷酸酶(alkaline phosphatase,ALP)、L-γ-谷氨酰转肽酶(L-γ-glutamyl transpeptidase,GGT)、甘油三酯(triglyceride,TG)、葡萄糖(glucose,GLU)和尿酸(uric acid,UA)水平与体重指数(body mass index,BMI)呈正相关(r值分别为0.289、0.309、0.285、0.245、0.125、0.203和0.360,P < 0.05),高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)水平与BMI呈负相关(r = -0.284,P < 0.05)。血清ALT于术后3个月显著下降,GGT、TG、GLU水平于术后1个月显著下降,至术后1年,各指标水平均明显低于术前(P < 0.05)。HDL-C水平于术后逐渐升高,6个月时显著升高(P < 0.05)。结论:MS可在短期内改变多数生化指标,有效改善肥胖患者肝功能和降低血脂。

    Abstract:

    Objective:To investigate the changes of serum liver and kidney function and blood lipid indexes in obese patients within one year after metabolic surgery(MS). Methods:A retrospective analysis was performed on 119 patients who received metabolic surgery(MS) in the First Affiliated Hospital of Nanjing Medical University. Venous blood samples were collected for serum biochemical tests before and immediately,1,3,6 and 12 months after the surgery,respectively. Results:The preoperative levels of alanine transaminase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),L-γ-glutamyl transpeptidase(GGT),triglyceride(TG),glucose(GLU) and uric acid(UA) were positively correlated with body mass index(BMI)(r = 0.289,0.309,0.285,0.245,0.125,0.203 and 0.360,P < 0.05),while high-density-lipoprotein cholesterol(HDL-C) level was negatively correlated with BMI (r = -0.284,P < 0.05). ALT,GLU,GGT and TG levels decreased significantly after surgery at different time(ALT:3 months; GGT,TG,GLU:1 month). One year after operation,each index was significantly lower than that before operation(P < 0.05). The postoperative level of HDL-C gradually increased with time, and significantly increased 6 months after operation(P < 0.05). Conclusion:MS can change most biochemical indicators in a short term and effectively improve liver function and reduce blood lipid levels of obese patients.

    参考文献
    相似文献
    引证文献
引用本文

任 真,宋为娟.代谢手术前后患者肝肾功能和血脂水平变化[J].南京医科大学学报(自然科学版),2022,42(4):542-548

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2021-05-19
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2022-04-25
  • 出版日期:
通知关闭
郑重声明