Objective：This study aims to evaluate the reliability of salivary gland ultrasonic Young’s modulus（SGYM）in the diagnosis of Sjogren’s syndrome（SS）. Methods：SGYM of parotid gland，submandibular gland and sublingual gland in 45 patients with SS and 51 healthy volunteers were observed，and the differences of SGYM between the two groups were evaluated. To evaluate the consistency of SGYM measured by physicians and between physicians，the effects of gender，age，height，weight and gland thickness on the measurement of SGYM were observed. Results：There was no significant difference in bilateral SGYM between SS group and healthy group（P > 0.05）. The differences of SGYM between SS group and healthy group were statistically significant（P < 0.05）. The SGYM measured within and among doctors has good consistency. The intra group correlation coefficient within doctors is 0.751~0.933. The differences of the average value measured between doctors were 96.43%~99.02% within the consistency limit and its 95% confidence interval. SGYM was not affected by gender，age，height，weight and gland thickness. Conclusion：Regardless of SS patients or healthy volunteers，SGYM is not affected by the factors of examiners and subjects，and has good reliability.