H3K27me3在肿瘤中的研究进展
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江苏省妇幼健康科研项目(F201871)


Research progress of H3K27me3 in tumors
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    摘要:

    组蛋白H3第27位赖氨酸三甲基化(trimethylated histone H3 at lysine 27,H3K27me3)是最常见的组蛋白甲基化修饰之一,由多梳抑制复合物2产生,而多梳抑制复合物2组成部分改变,如zeste基因增强子人类同源物2功能改变或过表达会表现出H3K27me3表达失衡,使细胞增殖分化失控,导致肿瘤发生。目前已在多种肿瘤中发现H3K27me3的组蛋白修饰缺失,例如乳腺癌、卵巢癌和胰腺癌等。然而,H3K27me3在不同肿瘤中的表达和预后存在异质性。本文总结并探讨了H3K27me3在不同肿瘤中的表达、生物学功能及其对肿瘤的诊断、治疗及预后的价值,为肿瘤研究提供新思路。

    Abstract:

    Trimethylated histone H3 at lysine 27(H3K27me3)is one of the most common histone methylation modifications and is produced by polycomb repressive complex 2,while changes in the components of polycomb repressive complex 2,such as altered function or overexpression of enhancer of zeste homolog-2 will show an imbalance in H3K27me3 expression,resulting in uncontrolled cell proliferation and differentiation and leading to tumorigenesis. Loss of histone modification of H3K27me3 has been found in a variety of tumors,for example,breast,ovarian,and pancreatic cancers. However,there is heterogeneity in the expression and prognosis of H3K27me3 in different tumors. In this paper,the expression and biological function of H3K27me3 in different tumors and its value in the diagnosis,treatment and prognosis of tumors were summarized and investigated,providing new ideas for the study of tumors.

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徐静纯,王 聪. H3K27me3在肿瘤中的研究进展[J].南京医科大学学报(自然科学版),2022,42(6):897-902

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  • 收稿日期:2022-02-20
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  • 在线发布日期: 2022-06-21
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