This article discussed extensively how to apply product responsibility in the infringement of blood product from the perspectives of law application, the principle of clarifying responsibility, the distribution of proof burden and the relief of responsibility. The author argued that the burden of proof of causality in this kind of infringement should be inverted because it was also belong to the medical infringement. The author also suggested that the burden of proof of the product defect should also be inverted due to the principle in distributing the proof burden and the Article 7 of Proof Regulation.