Objective:To understand the differences in the demand of health education of diabetes with different education degree,and propose ways to enhance manner and promote the effect of health education. Methods:A questionnaire survey was conducted with 502 diabetes in five 3A-grade hospitals of Nanjing. Results:There were statistically significant difference in ten contents,such as technology and note of insulin injections,the effects and adverse reactions of medication. High education level diabetes had higher demand for the effects and adverse reactions of medication,the time and project of regular review. There were also statistically significant differences in diabetes with different education degree. Compared to the low-skilled,diabetes with higher education degree had higher demand in collecting health information and subscribing to newspapers and magazines. Conclusion:Individualized health education is important. We need focus on the use of modern means,such as telephone and internet,and pay attention to the guidance and psychological counseling of families of diabetes.