植入式芯片系统调控家兔血压的实验研究
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Effect of Implanted Chip System on Blood Pressure Regulation in Rabbits
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    摘要:

    目的:评价植入式芯片系统调控血压的效果.方法:麻醉状态下记录家兔平均动脉压(MAP)和心率(HR).根据调定点学说,设计了一种植入式芯片系统,根据血压的反馈信息,经过芯片运算处理,即时改变刺激主动脉神经(ADN)的脉冲频率,从而调控血压.每只家兔分别给予两次芯片系统控制的血压调控,持续时间分别为15 min和60min.结果:与对照相比,第一次调控和第二次调控分别使平均动脉压(MAP)降低(32.0±6.6)mmHg和(27.4±6.2)mmHg,差异均有显著性,而调控前(对照)与调控结束后(恢复期)的MAP水平差异无显著性.与对照相比,两次调控均引起HR显著降低.调控结束后MAP和HR均迅速恢复至正常水平,未产生反跳.结论:植入式芯片系统能有效地将血压控制在设定范围,且未产生适应现象.

    Abstract:

    Objective: To evaluate the efficiency of an implanted chip system on blood pressure regulation.Methods: The mean arterial pressure (MAP) and heart rate (HR) were recorded in anesthetized rabbits. Based on the set point theory, an implanted chip system was designed to regulate the blood pressure by stimulating the aortic depressor nerve (ADN) according to the feedback of blood pressure. The blood pressure regulation induced by the implanted chip system was carried out twice (lasted for 15 min and 60 min respectively) and the change of MAP and HR during the regulation was compared with the control. Results: There was a significant decrease of MAP during the first regulation ([-32.0 ± 6.6] mmHg) and second regulation ([-27.4 ± 6.2] mmHg) compared with the control (P <0.01). The HR was also significantly decreased during regulation compared with the control. Both MAP and'HR returned to the baseline immediately without rebound after the regulation ceased. Conclusion: The implanted chip system can regulate the blood pressure successfully and keep the blood pressure in a lower constant level without adaptation.

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高兴亚,王汉军,朱国庆,郭瑞,张枫,张颖,陆祖宏.植入式芯片系统调控家兔血压的实验研究[J].南京医科大学学报(自然科学版),2004,18(6):

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