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Study of the immunoisolating effects of barium-alginate microencapsulation on rat islets allograft survival
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    Objective: To evaluate the immunoisolating effects of barium-alginate microencapsulation on islets allograft survival. Methods: The nonmicroencapsulated and microencapsulated islets were transplanted under the kidney capsule or intraperitoneally into Wistar rat with STZ-induced diabetes. The blood glucose and insulin secretion of grafts were observed. Graft function was tested by oral rats was associated with normal glucose and insulin profiles in response to OGTT. Conclusion: Microencapsulation with barium-alginate membrane can prolong islet survival and protect islets against allorejection.

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Mei Zhang, Chao Liu, Cuiping Liu, Youwen Qin, Zhaosun Zhen.[J].南京医科大学学报(自然科学版),2005,19(2):

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