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Experimental study of changes of TNF-α in rabbits with steroid-induced avascular necrosis of femoral head
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    Objective: To explore the effect of tumor necrosis factor-α(TNF-α)on the occurrence of steroid-induced avascular necrosis of femoral head(SANFH). Methods: Twenty-four rabbits were firstly divided into void group ( n = 12) and model group ( n =two groups were killed respectively to observe whether the model was successful. The level of TNF-α in serum of the residual rabbits of the two groups was examined in Radioimmunoassay method. Results: The level of TNF-α in model group is significantly higher than that in void group( P <0.001) under the premise of the model of SANFH success by histological observation. Conclusion: The rise of level of TNF-α may be one of the most important factors in the occurrence of SANFH.

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Puwei Yuan, Xijing He, Dong Wang, HaoPeng Li, Binshang Lan, Huiru Lu.[J].南京医科大学学报(自然科学版),2005,19(3):

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