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Effects of apigenin on cell proliferation of human pancreatic carcinoma cell line BxPC-3 in vitro
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    Objective: To observe the effects of apigenin on cell proliferation of human pancreatic carcinoma cell line BxPC-3 in vitro. Methods:The inhibitive effects of apigenin at different concentrations(0 -滋mol/L, 100 -滋mol/L, 200 -滋mol/L, and 400 -滋mol/L) on human pancreatic carcinoma cell line BxPC-3 were detected by MTT assays, transmission electron microscope,agarose gel electrophoresis and flow cytometry. The immunohistochemistry was used to detect the expression of Bcl-2 and Bax gene. Results:Apigenin at different concentrations could inhibit the proliferation of human pancreatic carcinoma cell lines BxPC-3, and the inhibitive effect was dose-dependent. The cell cycle of pancreatic carcinoma cells was arrested at G2/M phase. The results of immunohistochemistry showed that the density of apigenin increased, and the expression of Bcl-2 gene was reduced gradually. At the same time the expression of Bax gene was enhanced. Conclusion:Apigenin could inhibit the proliferation of human pancreatic carcinoma cell lines BxPC-3 in vitro. The effect of apoptosis was accompanied with the expression of Bcl-2 decrease and Bax increase.

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Jiancang Ma, Qiang Li, Jun Zhao, Ying Guo, Qinghua Su, Zongzheng Ji.[J].南京医科大学学报(自然科学版),2007,(2):94-98

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  • 收稿日期:2006-10-31
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