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The effect of Nifedipine on the expression of type I collagen in gingival fibroblasts
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This work was supported by the Natural Science Foundation of the Department of Educational of Jiangsu(BK2006172)

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    Abstract:

    Objective:To investigate the effect of nifedipine(calciumchannel blocker) on the expression of collagen in gingival fibroblasts invitro. Methods:Primarily gingival fibroblasts were cultured and incubated with various concentrations of nifedipine(108μg/L, 360μg/L and 1200μg/L)for 5 days. Gingival fibroblasts were primarily cultured derived from nifedipine responders and non-responders in the presence of 360μg/L nifedipine. Enzyme-linked immunosorbent assay was used to evaluate the amount of type I collagen. Cell proliferation was measured by cell counting with evaluating MTT value. Results:The expressions of collagen and cell proliferation were significantly different among the high concentration groups and the others on the fifth day, especially higher in 360μg/L and 1200μg/L groups and also different among nifedipine responders and non-responders. Conclusion:The expression of collagen and cell proliferation may be concerned with the biological mechanism for gingival overgrowth.

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Bei Li, Weibin Sun, Yong Ji.[J].南京医科大学学报(自然科学版),2008,28(2):92-95

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