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Using SELDI-TOF-MS technology for screening serum markers of hepatic carcinoma in rats
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This study was supported by the Science Foundation of the Ministry of Health of China(No.wkj2004-2-12)

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    Abstract:

    Objective: To identify potential serum markers of hepatic carcinoma in rats through Surface-Enhanced Laser Desorption Ioniza-tion-Time of Flight-Mass Spectrometry(SELDI-TOF-MS) Technology. Methods: A rat model of hepatic carcinoma was established. The serum samples of hepatic carcinoma and normal rats were analyzed via SELDI-TOF-MS Technology. The changes of the serum protein fingerprint patterns were observed between the experimental group of hepatic carcinoma and the controls. The analysis was conducted by statistical software-Biomarker Wizard. Results: Fifty-six protein peaks in the serums were found. Within m/z 0-20 000, the protein peaks of m/z 1158, 8 835 and 15 302 of hepatic carcinoma serums were obviously higher in the rat models compared with those in the controls(P < 0.01). Conclusion: Three peaks were considered as potential biomarkers according to the serum protein fingerprint patterns of the hepatic carcinoma group and the control group.

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Xiaoqin Jia, Yuefang Liu, Kaikun Liu, Qi Tang, Zhenqing Feng, Jianping Zhang.[J].南京医科大学学报(自然科学版),2008,28(5):286-289

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  • 收稿日期:2008-07-21
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