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HERG K+ channels expression in gastric cancers and analysis of its regulation in tumor cell proliferation and apoptosis
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This work was supported by a grant from the Natural Science Foundation of China(30772128)

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    Objective: To investigate the expression of herg1 gene in tumor tissues from gastric carcinomas and gastric carcinoma cell lines, and study the relationship between HERG K+ channel expressions and tumor cell proliferation and apoptosis. Methods: RT-PCR and PCR assays were used to detect the expression of herg1 gene in 64 gastric carcinomas and the gastric cancer cell line SGC-7901. Blocking the HERG K+ channels was used to evaluate their effects on tumor cell proliferation and apoptosis. Results:The statistically significant expression of herg1 gene was detected in all the gastric cancers and SGC-7901 cells, but not in normal tissues. The HERG K+ channel blocker, E-4031, increased the cell population in G0/G1(P < 0.05) and the number of apoptotic tumor cells(P < 0.05). Conclusion: HERG K+ channels were expressed in all gastric carcinomas tested and these channels appear to modulate tumor cell proliferation and apoptosis.

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Qing Lü,Huiyu Li, Xiaoming Lu, Guobin Wang.[J].南京医科大学学报(自然科学版),2009,29(3):157-162

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  • 收稿日期:2009-02-26
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