Objective:To explore the clinical efficacy and safety of Shuanghua Baihe Tablet in the treatment of erosive oral lichen planus(EOLP), and to provide more ideas and options for the treatment of EOLP. Methods:Sixty EOLP patients were divided into two groups randomly.The experimental group was given Shuanghua Baihe Tablets and the control group was given Transfer Factor Capsules.Both groups were treated with triamcinolone acetonide oral ointment and Xipayi mouth rinse at the same time.The changes of clinical symptoms and signs were compared before treatment and after treatment for one week between the two groups. And the blood routine, liver and renal function indexes before and after treatment were compared. Results:EOLP patients in the experimental group and the control group had less erosion area and less pain after treatment of one week(P<0.05).The total effective rate was 93.3% in the experimental group and 70.0% in the control group. There was significant difference between the two groups(P＜0.05).There was no significant difference in the related indexes of blood routine and liver and renal function before and after treatment in EOLP patients given Shuanghua Baihe Tablets (P > 0.05). Conclusion:Shuanghua Baihe Tablet is more effective than Transfer Factor Capsule in the treatment of EOLP, and it is safe in clinical use.