IA期肺腺癌预后高危影响因素及术后辅助治疗的研究进展
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南京医科大学附属无锡市人民医院

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江苏省科技计划重点研发项目(BE 2022697)


Research progress on high-risk prognostic factors and postoperative adjuvant therapy for stage IA lung adenocarcinoma
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    摘要:

    目前国内外的肺癌筛查指南均推荐采用低剂量螺旋CT(low-dose computed tomography,LDCT)用于肺癌筛查,早期肺腺癌的检出率得到显著提升。根据中华医学会肺癌临床诊疗指南(2024版)建议,选择手术治疗且切缘阴性(R0)IA(T1a/b/cN0)期肺癌患者,术后定期随访即可,无需辅助治疗(I类推荐证据)。近期的临床研究揭示,IA期肺腺癌患者仅接受手术治疗的预后结果受到多种因素的影响。为进一步提高患者预后,关于是否需要进行术后辅助治疗的探讨不断涌现,尽管目前尚未形成统一的治疗标准,但这一议题仍具有重要的研究价值。文章综述了肿瘤大小、实性成分占比、微乳头及实体亚型占比、脉管侵犯(lymphovascular invasion,LVI)、是否合并气腔播散(spread through air space,STAS)等因素对IA期肺腺癌预后的影响,并探讨了最新的术后辅助治疗方案及其效果,为IA期肺腺癌的术后治疗提供新的思路。

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    Current domestic and international lung cancer screening guidelines recommend the use of low-dose spiral computed tomography(LDCT)for lung cancer screening,which has significantly improved the detection rate of early-stage lung adenocarcinoma.According to the Chinese Medical Association's Lung Cancer Clinical Diagnosis and Treatment Guidelines(2024 Edition),patients with stage IA(T1a/b/cN0)lung adenocarcinoma who undergo surgery with negative surgical margins(R0)can have regular follow-ups postoperatively without the need for adjuvant therapy(Class I recommendation, evidence-based).Recent clinical studies have revealed that the prognosis of patients with stage IA lung adenocarcinoma who only receive surgical treatment is influenced by various factors. To further improve patient outcomes, discussions on the need for postoperative adjuvant therapy continue to emerge. Although a unified treatment standard has not yet been formed, this topic remains of significant research value. This article reviews the impact of factors such as tumor size, solid component ratio, micropapillary and solid subtype proportions, lymphovascular invasion(LVI),and the presence of spread through air spaces(STAS)on the prognosis of stage IA lung adenocarcinoma, and discusses the latest postoperative adjuvant treatment plans and their outcomes, providing new insights into the postoperative treatment of stage IA lung adenocarcinoma.

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  • 收稿日期:2024-11-28
  • 最后修改日期:2025-04-11
  • 录用日期:2025-06-05
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