ⅠA期肺腺癌预后高危影响因素及术后辅助治疗的研究进展
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南京医科大学附属无锡人民医院胸外科,江苏 无锡 214023

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R734.2

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江苏省科技计划重点研发项目(BE2022697)


Research progress on high ⁃ risk prognostic factors and postoperative adjuvant therapy for stage Ⅰ A lung adenocarcinoma
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Department of Thoracic Surgery,the Affiliated Wuxi People’s Hospital of Nanjing Medical University,Wuxi 214023 ,China

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    摘要:

    目前国内外的肺癌筛查指南均推荐采用低剂量螺旋CT筛查肺癌,早期肺腺癌的检出率得到显著提升。根据中华医学会肺癌临床诊疗指南(2024版)建议,选择手术治疗且切缘阴性(R0)ⅠA期(T1a/b/cN0)肺癌患者,术后定期随访即可,无需辅助治疗(Ⅰ类推荐证据)。近期的临床研究揭示,ⅠA期肺腺癌患者仅接受手术治疗的预后结果受到多种因素的影响。尽管目前尚未形成统一的治疗标准,但关于是否需要进行术后辅助治疗这一问题仍具有重要研究价值。文章综述了肿瘤大小、 实性成分占比、微乳头及实体亚型占比、脉管侵犯、是否合并气腔播散等因素对ⅠA期肺腺癌预后的影响,并探讨了最新的术后辅助治疗方案及其疗效,为ⅠA期肺腺癌的术后治疗提供新思路。

    Abstract:

    At present,the domestic and international lung cancer screening guidelines recommend the use of low - dose spiral computed tomography(LDCT)for lung cancer screening,which significantly improved the detection rate of early - stage lung adenocarcinoma. According to the recommendation of the Chinese Medical Association guideline for clinical diagnosis and treatment of lung cancer(2024 edition),patients with stage ⅠA(T1a/b/cN0)lung adenocarcinoma who undergo surgery with negative surgical margins(R0)can be followed up regularly after surgery without adjuvant therapy(classⅠrecommendation,evidence-based). Recent clinical studies have revealed that the prognosis of patients with stage ⅠA lung adenocarcinoma who only receive surgical treatment is influenced by multiple factors. Although no unified treatment standard has been established,the issue of whether postoperative adjuvant therapy is necessary is still of great research value. This article reviewed the impact of factors such as tumor size,solid component ratio,micropapillary and solid subtype proportions,lymphovascular invasion(LVI),and the presence of spread through air spaces(STAS)on the prognosis of stageⅠA lung adenocarcinoma,and discussed the latest postoperative adjuvant treatment plans and their outcomes,providing new insights into the postoperative treatment of stageⅠA lung adenocarcinoma.

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成永奇,陈乐延,郑明峰.ⅠA期肺腺癌预后高危影响因素及术后辅助治疗的研究进展[J].南京医科大学学报(自然科学版),2025,45(6):891-899

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  • 收稿日期:2024-11-28
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  • 在线发布日期: 2025-06-10
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