Objective：To analyze the biological functions and gene sequence information of long non - coding RNA（lncRNA） uc004coz.1 associated with coronary artery disease（CAD）. Methods：LncRNAs were analyzed in plasma sequencing results of CAD patients. The target lncRNA uc004coz.1 was identified by clinical sample verification. Fluorescence in situ hybridization（FISH） method was used to locate uc004coz.1 in human umbilical vein endothelial cell（HUVEC），and its biological function was analyzed after knockdown with si - uc004coz.1. The effect on cell proliferation and migration was analyzed by CCK - 8，Transwell，EdU，flow cytometry，and Western blot. The full length sequence information of uc004coz.1 was obtained by rapid - amplication of cDNA ends （RACE）technique. Results：uc004coz.1 was down-regulated in CAD patients，and uc004coz.1 is mainly located in the nucleus. Cell proliferation and migration were significantly weakened after uc004coz.1 knockdown，and cell cycle - related proteins Cyclin D1 and Cyclin E1 were down-regulated. By comparing the RNA sequence and genome in the Ensembl database，we obtained that uc004coz.1 corresponding chromosome is Homo sapiens mitochondrion，complete genome（sequence ID：NC_01292-1）. The location of uc004coz.1 in the database is 15 998-16 569. The 5′-RACE sequencing results showed that the 5′ terminal position was 16 033. The 3′-RACE sequencing results showed that the terminal position of 3′ -RACE was 16 417. Conclusion：Understanding the biological function of down-regulated lncRNA uc004coz.1 in the plasma of CAD patients and analyzing its gene sequence can provide a target for the study of the mechanism of CAD and provide a theoretical basis for further study of uc004coz.1.