基于卷积神经网络的胃癌病理图像分类诊断与分级识别
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1南京医科大学第一附属医院肿瘤科,江苏 南京 210029 ; 2.南京医科大学第一临床医学院临床医学系,江苏 南京 211166 ; 3.东南大学能源与环境学院动力工程及自动化系,江苏 南京 211189 ; 4.南京医科大学部省共建肿瘤个体化医学协同创新中心,江苏 南京 211166 ; 5.睢宁县人民医院肿瘤科,江苏 徐州 221200

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国家自然科学基金(82102981);江苏高校“青蓝工程”(KY102R202412);中国博士后科学基金第75批面上资助(2024M751224);南京市博士后项目[BSHNJ2023003(JC23)];北京希思科临床肿瘤学研究基金会(Y-Young2024-0152);部省共建肿瘤个体化医学协调创新中心青年项目(2024CICCPMHR033);胃癌免疫治疗专病队列研究(JZ214490202106052);江苏省高等学校大学生创新创业训练计划(X2025103120042)


Classification and grading recognition of gastric cancer pathological images based on convolutional neural networks
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1Department of Oncology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029 ; 2.Departmentof Clinical Medicine,the First school of Clinical Medicine,Nanjing Medical University 211166 ; 3.Department of PowerEngineering and Automation,School of Energy and Environment,Southeast University,Nanjing 211189 ; 4.Collaborative Innovation Center of Personalized Oncology Medicine,Ministry of Education and Jiangsu Province,Nanjing Medical University,Nanjing 211166 ; 5.Department of Oncology,Sui Ning County People’s Hospital,Xuzhou 221200 ,China

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    摘要:

    目的:基于深度学习技术,建立胃癌病理切片的分类诊断模型与分级模型,评估模型性能。方法:基于公开网络资源收集胃癌和非癌组织分类诊断识别数据集与胃癌分级识别数据集。对数据进行数据增强,划分为训练集、验证集和测试集。初始阶段,构建17种卷积神经网络(convolutional neural network,CNN)模型,统一设置初始训练参数,对17个模型进行胃癌和非胃癌分类识别训练。训练结束后,以模型在测试集上的识别准确率、训练耗时作为评价指标,全面评估不同模型架构的效能。基于这些指标,筛选出效能最优的架构,进一步优化训练,构建胃癌分类诊断识别模型。分类模型完成后,基于分类模型的基础构建胃癌分级模型,在胃癌分级模型的训练过程中,训练17个分级网络,根据性能指标筛选出适合作为基模型的网络。在基模型确定后,分别采用Voting和Stacking方法进行集成学习,并与单模型进行比较。探究集成学习对性能提升的影响,构建胃癌分级识别模型。结果:在胃癌分类诊断模型训练中,Xception经对比被选为最终分类诊断模型的网络。经过参数调整与训练后,最终胃癌分类诊断模型在测试集上表现的准确率为98.13%、灵敏度为98.11%、特异度为98.11%、F1分数为 98.12%、受试者工作特征(receiver operating characteristic,ROC)曲线下面积(area under the curve,AUC)为0.998;胃癌分级模型训练中,以随机森林为代表的堆叠法相对于以硬投票法为代表的投票法拥有较大的提升。以随机森林集成模型为最终分级模型,其准确率为 95.06%、灵敏度为 94.77%、特异度为 98.36%、F1 分数为 94.82%,良性 AUC 为 0.999,管状低分化腺癌 AUC 为 0.981,管状中分化腺癌AUC为0.990,管状高分化腺癌AUC为0.995。结论:两个模型都拥有良好的识别性能,证明了利用CNN 实现对胃肿瘤病理图像进行高精度分类诊断及分级的可行性,实现了迁移-集成联合框架对胃肿瘤图像的分级运用,有望应用于医院智能化诊断辅助系统。

    Abstract:

    Objective:To establish classification and grading models for gastric cancer pathological sections based on deep learning technology,and to evaluate the performance of these models. Methods:Classification and grading datasets for gastric cancer and noncancerous tissues were collected from public online resources. Data augmentation was performed,and the dataset were divided into training,validation,and test sets. In the initial stage,17 convolutional neural network(CNN)architectures were constructed,and the initial training parameters were uniformly set to train these 17 models for the classification of gastric cancer and non-cancerous tissues. After training,the recognition accuracy on the test set and the training time were used as evaluation indicators to comprehensively assess the efficacy of different model architectures. Based on these indicators,the optimal architecture was selected for further optimization and training to construct the gastric cancer classification model. After the completion of the classification model,the gastric cancer grading model was built based on the foundation of the classification model. During the training of the gastric cancer grading model,17 grading networks were trained,and suitable base models were selected according to performance indicators. After the base model was determined,voting and stacking methods were applied for ensemble learning and compared with single models to explore the impact of ensemble learning on performance improvement and to construct the gastric cancer grading model. Results:In the training of the gastric cancer classification model,the Xception network was selected as the final classification model after comparison. After parameter adjustment and training,the final gastric cancer classification model achieved an accuracy of 98.13%, sensitivity of 98.11%,specificity of 98.11%,F1 score of 98.12%,and AUC of 0.998 on the test set. In the training of the gastric cancer grading model,the stacking method represented by random forest showed significant improvement compared to the voting method represented by hard voting. The ensemble model based on random forest was selected as the final grading model,with an accuracy of 95.06%,sensitivity of 94.77%,specificity of 98.36%,and F1 score of 94.82%. The area under the receiver operating characteristic (ROC - AUC)curve values were 0.999 for benign,0.981 for poorly differentiated tubular adenocarcinoma,0.990 for moderately differentiated tubular adenocarcinoma,and 0.995 for well - differentiated tubular adenocarcinoma. Conclusion:Both models demonstrated excellent recognition performance,proving the feasibility of using CNN to achieve high - precision classification and grading of gastric tumor pathological images. The transfer-learning and ensemble-learning framework was successfully applied to the grading of gastric tumor images and holds promise for integration into hospital intelligent diagnostic assistance systems.

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吴邦钰,王志霄,项景轩,孙立,马玲.基于卷积神经网络的胃癌病理图像分类诊断与分级识别[J].南京医科大学学报(自然科学版),2026,46(4):520-532

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  • 收稿日期:2025-03-26
  • 最后修改日期:2025-09-17
  • 录用日期:2025-09-19
  • 在线发布日期: 2026-04-14
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