文章摘要
Yuanyuan Mi,Qianqian Yu,Zhichao Min,Bin Xu,Lifeng Zhang,Wei Zhang,Ninghan Feng,Lixin Hua.[J].南京医科大学学报,2010,(5):365~373
Arg462Gln and Asp541Glu polymorphisms in ribonuclease L and prostate cancer risk: a meta-analysis
投稿时间:2010-04-22  
DOI:10.7655
中文关键词: 
英文关键词: ribonuclease L, polymorphism, prostate cancer, risk, meta-analysis
基金项目:
作者单位
Yuanyuan Mi Department of Urology, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China 
Qianqian Yu Department of Ophthalmology, Wuxi People's Hospital Affiliated with Nanjing Medical University, Wuxi 214023,Jiangsu Province, China 
Zhichao Min Department of Urology, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China 
Bin Xu Department of Urology, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China 
Lifeng Zhang Department of Urology, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China 
Wei Zhang Department of Urology, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China 
Ninghan Feng Department of Urology, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China 
Lixin Hua Department of Urology, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China 
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中文摘要:
      
英文摘要:
      Objective: The association between ribonuclease L (RNASEL) gene polymorphisms and prostate cancer risk has been widely reported, but the results of these studies remained controversial and underpowered. We performed a meta-analysis of 28 studies to evaluate the association between Arg462Gln and Asp541Glu polymorphisms in the RNASEL gene and prostate cancer risk. Methods: Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association between RNASEL polymorphisms and prostate cancer risk. Results: A significantly increased prostate cancer risk was found for the Arg462Gln polymorphism in Africans (Gln/Gln vs Arg/Arg: OR = 2.50, 95%CI = 1.28-4.87; Gln/Gln vs Gln/Arg + Arg/Arg: OR = 2.54, 95%CI = 1.30-4.95), but not in Europeans and Asians. Additionally, the Asp541Glu polymorphism was associated with increased total prostate cancer risk (Glu-allele vs Asp-allele: OR = 1.04, 95%CI = 1.01-1.07; Glu/Glu vs Asp/Asp: OR = 1.22, 95%CI = 1.03-1.46; Glu/Glu vs Glu/Asp + Asp/Asp: OR = 1.09, 95%CI = 1.02-1.16). In the stratified analysis for the As-p541Glu polymorphism, there was a significantly increased prostate cancer risk in Africans and Europeans, and in hospital-based prostate cancer cases. Conclusion: The meta-analysis results showed evidence that RNASEL Arg462Gln and Asp541Glu polymorphisms are associated with prostate cancer risk and could be low-penetrance prostate cancer susceptibility biomarkers.
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