文章摘要
袁孝如,裴曙光,李晓璐.乙醇对伏核神经元电活动的影响及与内源性阿片肽的关系[J].南京医科大学学报,2000,20(01):
乙醇对伏核神经元电活动的影响及与内源性阿片肽的关系
Effects of Ethanol on Neuronal Activity of Rat Nucleus Accumbens Slices and It′s Interactions with Endogenous Opiate Peptides
  
DOI:10.7655
中文关键词: 伏核, 脑片, 乙醇, 纳洛酮, 细胞外记录
英文关键词: nucleus accumbens, brain slice, ethanol, naloxone, extracellular recording
基金项目:
袁孝如  裴曙光  李晓璐
南京医科大学第一附属医院神经外科研究室;生理学教研室 南京 210029;生理学教研室 南京 210029;
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中文摘要:
      目的 评估介入性栓塞治疗颈内动脉-海绵窦瘘(carotid cavernous fistula,CCF)的临床疗效。方法 6例颈内动脉-海绵窦瘘患者,采用经皮股动脉径路、可脱囊栓塞治疗。其中1例伴颈外动脉-海绵窦瘘患者,结合颈外动脉颗粒性体塞。结果 6例CCF栓塞均获成功,其中2例栓塞 后保持颈内动脉通畅,另4例结合同侧颈内动脉栓闭。本组无并发症发生。结论 CCF的介入治疗创伤小、疗效好,是CCF
英文摘要:
      Objective The effects of ethanol (0.2 μmol/L) on the spontaneous electrical activity in the neurons of slice preparation of the nucleus accumbens septi (NAcc) was investigated. Methods Use extracellular recording.Results (1) In response to the application of ethanol into the superfusate for 10~15 min, spontaneous discharge rate (SDR) of 25 neurons was increased significantly, then, it was decreased (P<,0.01). This decreasing responses could be reversed by 0.2 μmol/L opiate antagonist naloxone (Nal), which suggests ethanol may exert some effects through interactions with endogenous opiate peptide systems of their receptors. (2) Following the application of DAGO, U-50 and D-PEN for 5~10 min respectively, the effect of ethanol might be reinforced. By statistical analysis of ANOVA, we conclude that the effect of DAGO, the selective μ opiate receptor agonist, is stronger than other two opiate receptor agonists. Conclusion (1) The spontaneous electrical activity of the NAcc neurons can be inhibited by ethanol. The effect of ethanol will be involved in endogenous opiate system. (2) It is possible that μ opiate receptor has the strongest effect on the ethanol inhibitory action.
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