文章摘要
盛瑞兰,夏薇,朱广荣,钱思轩,刘翠萍,覃又文,刘超,侯馨德,武正炎,沈美萍.人甲状腺乳头状癌细胞对牛-TSH和去甲肾上腺素反应性的实验研究[J].南京医科大学学报,2000,20(01):
人甲状腺乳头状癌细胞对牛-TSH和去甲肾上腺素反应性的实验研究
Research of the Effect of the Cells of Thyroid Papillary Carcinoma to Bovine TSH and Norepinephrine
  
DOI:10.7655
中文关键词: 甲状腺肿瘤, 细胞培养, 促甲状腺激素, 去甲肾上腺素
英文关键词: thyroid neoplasms, cells culture, bovine thyrotropin, adrenergic neurotransmitters
基金项目:
盛瑞兰  夏薇  朱广荣  钱思轩  刘翠萍  覃又文  刘超  侯馨德  武正炎  沈美萍
南京医科大学第一附属医院普外科 南京 210029;南京医科大学第一附属医院普外科 南京 210029;南京医科大学第一附属医院普外科 南京 210029;南京医科大学第一附属医院内分泌科 南京 210029;南京医科大学第一附属医院内分泌科 南京 210029;南京医科大学第一附属医院内分泌科 南京 210029;南京医科大学第一附属医院血液科 南京 210029;南京医科大学第一附属医院血液科 南京 210029;南京医科大学第一附属医院血液科 南京 210029;南京医科大学第一附属医院血液科 南京 210029;
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中文摘要:
      目的 评估介入性栓塞治疗颈内动脉 -海绵窦瘘 (carotid cavernous fistula,CCF)的临床疗效。方法  6例颈内动脉 -海绵窦瘘患者 ,采用经皮股动脉径路、可脱球囊栓塞治疗。其中 1例伴颈外动脉 -海绵窦瘘患者 ,结合颈外动脉颗粒性栓塞。结果  6例 CCF栓塞均获成功 ,其中 2例栓塞后保持颈内动脉通畅 ,另 4例结合同侧颈内动脉栓闭。本组无并发症发生。结论  CCF的介入治疗创伤小、疗效好 ,是 CCF临床治疗的首选方法。
英文摘要:
      Objective To investigate the mechanisms of TSH-suppressing therapy using T4 on differentiated thyroid cancer. We evaluated the effection of the cells of pappillary carcinoma to bovine TSH and norepinephrine in vitrol. Methods The five samples of thyroid papillary carcinomas verified by frozen sections were cut off from the patients with thyroid cancer. They were dispersed by collagenase Ⅰ and trypsin and cultured in bottles, then the carcinoma cells were seeded in 96-well cell culture plates at 37℃ in 5%CO\-2 and 95%humidity for 72 h. The cells in the wells were separately stimulated with different doses of bovine TSH and norepinephrine. Results The thyroid cancer cells did not respond to bovine TSH, but were in response to norepinephrine which enhanced the proliferation of thyroid cancer cells. Conclusion The mechanisms of suppression therapy on differentiated thyroid cancer by T4 must be further investigated. Additionally, our results suggest that thyroid cancer is also under the regulation of adrenergic neurotransmitters.
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