文章摘要
高玉福,杨尚琪,王祥慧,董坚.霉酚酸酯应用对近期肾移植后急性排斥反应的预防[J].南京医科大学学报,2000,20(01):
霉酚酸酯应用对近期肾移植后急性排斥反应的预防
Application of MMF in Prevention of Acute Renal Transplantation Rejection in the Near Period of Post-operation
  
DOI:10.7655
中文关键词: 霉酚酸脂, 肾移植, 急性排斥
英文关键词: mycophenolate mofetil, renal transplantation, acute rejection
基金项目:
高玉福  杨尚琪  王祥慧  董坚
无锡市第二人民医院泌尿外科 无锡 214002;上海市第一人民医院泌尿外科 上海 200085;上海市第一人民医院泌尿外科 上海 200085;高淳县人民医院麻醉科.高淳 211300;
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中文摘要:
      目的 探讨糖尿病Ⅳ型胶原水平的变化及给予葛根素治疗后的变化。方法 测定血清Ⅳ型胶原与病程、糖基化血红蛋白、年龄、体质量指数的相关性;观察用葛根素前后的尿白蛋白、Ⅳ型胶原及血液流变化。结果 糖尿病患者Ⅳ型胶原水平明显升高(P〈0.05),早期糖尿病肾病组较正常白蛋白尿组Ⅳ型胶原水平明显升高(P〈0.05)。用葛根素治疗前后尿白蛋白降低。结论 葛根素对早期糖尿病肾病有治疗作用,其机制可能与抑制非酶糖基
英文摘要:
      Objective To observe the effect of mycophenolate mofetil (MMF) on prevention of acute renal transplantation rejection in the three months of post-operation. Methods 112 cases of renal transplant recipients were random divided into two groups: group MMF (2.0 g/d) and group azathioprine A (AZA). Recipients of the two groups simultaneously received similar doses of cyclosporin A(CsA) and steroids. Results Within three months, the incidences of acute rejection were 16.6%(10/60) in group MMF and 41.5%(22/52) in groups AZA respectively (P<,0.01). Of the 60 recipients in groups MMF, 5 cases emerged reduction of WBC and platelet and 3 cases of diarrhea, which all recovered after taper or cessation of the usage of MMF. No cases of liver or renal dysfunction were found in group MMF while 9 cases of liver dysfunction occurred in group AZA. Conclusion MMF can prevent and decrease acute renal transplantation rejection and side effects of MMF are slight and reversible.
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