抑肽酶对心脏手术血液保护量效关系的研究
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The Blood Conservation Research on Aprotinin Dosages and Effects in Cardiac Surgery
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    摘要:

    对抑肽酶的不同使用剂量和止血效果进行比较分析,探讨最佳应用方案;方法 82例心脏手术病人分为 大剂量、半量和小剂量抑肽酶组,以不同的给药方案进行引流量、血制品用量、血扛蛋白丢失量和血液抑肽酶浓度检测。结果 大剂量抑肽酶组与对照组相比,术后12、24h引流量减少54%、55%.总血红蛋白丢失量减少56%,总血制品用量减少65%。半 量抑肽酶组可使术后12、24h引流量减少49%和55%,与大剂量抑肽酶组相比无显著性差异。小剂量抑肽酶组可使术后引流 量减少约30%,血制品用量减少26%,与半量抑肽酶相比有显著性差异。结论 抑肽酶可明显减少体外循环术后的引流量和血 制品用量、其止血效果与剂量有关,作者推荐半量和小剂量抑肽酶方案。

    Abstract:

    Different aprotinin regimens and their hemostatic effects were comparatively analysed and the more appropriate aprotinin regimen was evaluated and discussed here. Methods Eighty-two open heart patients were divided into three groups. There were high-dose half-dose and low-dose aprotinin groups. Results It was shown that the high-dose aprotinin regimen could reduce postoperative drainage by 54%and 55%during the first 12 and 24 hours,meanwhile the hemoglobin loss and blood transfusion requirement were reduced by 56%and 65%respectively compared to the control group. The half-dose aprotinin regimen could reduce postoperative drainage by 49%and 55%in the first 12 and 24 hours ,which was not significantly different as compared with high-dose aprotinin group. The low-dose aprotinin regimen could reduce tube drainage and blood transfusion requirement by 30%and 26%, which had significant difference as compared to half dose aprotinin group. Conclusion The use of aprotinin could sig nificantly reduce postoperative drainage and blood transfusion requirement,the hemostatic effect was related to apro tinin dose. The half-dose and low-dose aprotinin regimen are recommended.

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陈亮,陈广明,朱秉智,季清泉,房士琦,陈亦江.抑肽酶对心脏手术血液保护量效关系的研究[J].南京医科大学学报(自然科学版),2000,20(03):

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