Objective：To evaluate the safety, clinical success rates, and short-term patency in patient with iliac artery and femoral multisegmental artery occlusive disease. Methods：Nineteen patients with iliac artery and femoral multisegmental artery occlusive disease were treated with endovascular therapy. The patients had chronic limb ischemia described as disabling claudication（fontain Ⅱb）in 15cases, restpain in 3 cases, ulcer in 1 case. The affected arteries receiving treatment included 8 iliac arteries with complete occlusion and 11 iliac arteries with critical stenosis（≥50％）, 3 common femoral arteries with complete occlusion or critical stenosis, 6 superficial femoral arteries with complete occlusion, 13 superficial femoral arteries with critical stenosis. Endovascular procedures were performed using introducer sheaths from contralateral femoral artery via aorta crotch to occlusive iliac artery. Results：There was no perioperative death. Total complication rate was 5.2%（one thrombosisn in stent）, and the technical success rate was 100%. The mean follow-up time was 5.5 months（range, 1 to 8 months）. The patency rate was 89%（17／19）. Conclusion：Endovascular therapy of iliac and femoral multisegmental artery occlusive disease is safe, convenient and effective, but the long-term curative effect need to be confirmed.