文章摘要
任子健,陆 倩,张永杰,王鹤鸣.变应性鼻炎大鼠翼腭神经节内NOS和NGF的表达变化[J].南京医科大学学报,2007,(2):129~132
变应性鼻炎大鼠翼腭神经节内NOS和NGF的表达变化
Expression of nitric oxide synthases and nerve growth factor in pterygopalatine ganglion of the allergic rhinitis rats
投稿时间:2006-06-01  
DOI:10.7655
中文关键词: 变应性鼻炎  一氧化氮合酶  神经生长因子  翼腭神经节  大鼠
英文关键词: allergic rhinitis  nitric oxide synthases  nerve growth factor  pterygopalatine ganglion  rat
基金项目:江苏省自然科学基金(BK2003103);南京医科大学科技发展基金资助项目(NY04001)
作者单位
任子健 南京医科大学人体解剖学系江苏 南京 210029 
陆 倩  
张永杰  
王鹤鸣  
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中文摘要:
      目的:观察一氧化氮合酶(NOS)和神经生长因子(NGF)在变应性鼻炎(AR)大鼠翼腭神经节内的表达变化。方法:建立AR大鼠模型,用HE染色方法观察鼻黏膜内腺体的变化;用组织化学的方法观察翼腭神经节内NOS表达的变化;用免疫荧光的方法观察翼腭神经节内NGF表达的变化。结果:实验组和正常组大鼠翼腭神经节内均有NOS和NGF表达,但实验组大鼠翼腭神经节内NOS和NGF表达均较正常组显著性增加(P < 0.01)。结论:NOS和NGF可能通过神经调节机制参与了AR的致病过程。
英文摘要:
      Objective:To investigate the expression level of nitric oxide synthases(NOS) and nerve growth factor(NGF) in pterygopalatine ganglion of the allergic rhinitis rats. Methods: The expression level of NOS and NGF was detected in pterygopalatine ganglion of the allergic rhinitis rats using histochemical and immunofluorescence staining methods respectively. Results:The number of labelled NOS-positive neurons and NGF-positive neurons was respectively increased significantly(P < 0.01) in pterygopalatine ganglion of the allergic rhinitis rats. Conclusion:NOS and NGF were probably involved in the pathologic mechanisms of the allergic rhinitis by the nerve regulation.
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