| 康苏娅,顾丽萍,谢满鑫,林 敏,马 翔,朱叶飞,沙家豪,刘嘉茵,周作民,韩素萍,冒韵东.核内不均一核糖核蛋白A2／B1在子宫内膜异位症组织中的表达[J].南京医科大学学报,2007,(5):449~451 |
| 核内不均一核糖核蛋白A2／B1在子宫内膜异位症组织中的表达 |
| Expression of heterogeneous nuclear ribonucleoprotein A2／B1 in endometriosis |
| 投稿时间：2006-11-13 |
| DOI：10.7655 |
| 中文关键词: 核内不均一核糖核蛋白A2／B1 子宫内膜异位症 免疫组织化学 Western blot |
| 英文关键词: hnRNP A2／B1 endometriosis immunohistochemistry Western blot |
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| 中文摘要: |
| 目的：研究核内不均一核糖核蛋白A2／B1（heterogeneous nuclear ribonucleoprotein A2／B1，hnRNP A2／B1）在正常子宫内膜、子宫内膜异位症（EMs）患者在位内膜、患者异位内膜间的表达差异。方法：用免疫组织化学法和Western blot分析，研究3例增生中晚期正常子宫内膜、3例增生中晚期EMs患者的在位内膜和异位内膜中，hnRNP A2／B1蛋白的表达差异。结果：hnRNP A2／B1主要表达于间质和腺上皮细胞的细胞核内，且EMs患者在位内膜和异位内膜中的表达强度，均低于正常内膜中的表达（P < 0.05）；而患者在位内膜和异位内膜中的表达，无明显差异（P > 0.05）。结论：hnRNP A2／B1可能参与EMs的发生和发展。 |
| 英文摘要: |
| Objective：To study the different expression of heterogeneous nuclear ribonucleoprotein A2／B1（hnRNP A2／B1） among normal endometria, eutopic and ectopic endometria of patients with endometriosis. Methods：The expression differences among three normal proliferate-stage endometria， three proliferatestage eutopic and ectopic endometria of patients with endometriosis was examined by immunohistochemistry and Western blot. Results：hnRNP A2／B1 was located in the nucleus of both epithelial glands and stroma. The expression level of hnRNP A2／B1 in ectopic and eutopic endometria of patients with endometriosis both were weaker than that in normal endometria（P < 0.05）, while the difference between ectopic and eutopic endometria in the patients was not significant（P > 0.05）. Conclusion：hnRNP A2／B1 may play an important role in the pathogenesis of endometriosis. |
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