文章摘要
陈汐敏,戚晓红,段 磊,朱利群,冯振卿,陈 强,吴 军.天冬氨酸-谷氨酸共聚物-甲硝唑纳米粒子的制备表征[J].南京医科大学学报,2007,(6):569~572
天冬氨酸-谷氨酸共聚物-甲硝唑纳米粒子的制备表征
Preparation and identification of poly aspartic acid-co-glutamic acid-metronidazole nanop-articles
投稿时间:2006-10-08  
DOI:10.7655
中文关键词: 纳米粒子  甲硝唑  阴道毛滴虫  天冬氨酸  谷氨酸
英文关键词: nanoparticle  metronidazole  trichomonas vaginalis  aspartic acid  glutamic acid
基金项目:南京市卫生局科技发展专项基金资助项目(ZKX0103)
作者单位
陈汐敏 南京医科大学卫生部抗体技术重点实验室江苏 南京 210029 
戚晓红 南京医科大学卫生部抗体技术重点实验室江苏 南京 210029 
段 磊 南京医科大学卫生部抗体技术重点实验室江苏 南京 210029 
朱利群 南京医科大学卫生部抗体技术重点实验室江苏 南京 210029 
冯振卿 南京医科大学卫生部抗体技术重点实验室江苏 南京 210029 
陈 强 南京大学表面和界面化学工程技术中心江苏 南京 210029 
吴 军 南京大学表面和界面化学工程技术中心江苏 南京 210029 
摘要点击次数: 921
全文下载次数: 95
中文摘要:
      目的:制备新型天冬氨酸-谷氨酸共聚物-甲硝唑(poly aspartic acid-co-glutamic acid-metronidazole,PAG-MTI)纳米粒子。方法:应用化学法合成PAG-MTI纳米粒子;通过红外光谱仪测定其化学结构、透射电镜及激光粒度分析仪分析微观形貌和粒径、紫外分光光度法测定载药量、透析法进行体外释放试验,对其化学结构和物理性质进行了系列表征。结果:合成的PAG-MTI纳米粒为球形,粒径198.9 nm,载药量12%,体外释放试验表明PAG-MTI的释药速率明显延缓,释放1 h与24 h,累积释放百分比分别为12.19%和47.51%。结论:化学合成法制备的新型PAG-MTI具有较好的缓释作用,有望通过进一步优化改进以用于临床滴虫性生殖道炎症的治疗。
英文摘要:
      Objective:To prepare and identify poly aspartic acid-co-glutamic acid-metronidazole(PAG-MTI) nanoparticles.Methods:Metronidazole was conjugated into polymers. The structure, morphology and particle size of PAG-MTI were characterized by infrared spectrophotometry, ultraviolet spectrophotometry, transmission electron microscope and laser diffraction-based particle size analyzer. Metronidazole release behavior from these polymers was also determined in vitro. Results:PAG-MTI nanoparticles were spherical in morphology; drug loadings were 12%, and average size of nanoparticles was198.9 nm. The release of metronidazole in PAG-MTI was sustained obviously. The accumulation rate of metronidazole was 12.19% at 1 h, and 47.51% at 24 h after released. Conclusion:PAG-MTI nanoparticles by chemosynthesis can delay metronidazole release in vitro. It may be considered as a promising approach in the treatment of T.vaginalis.
查看全文   查看/发表评论  下载PDF阅读器
关闭