文章摘要
王凤良,凌立君,沈恩超,刘晓安,王水.血清Tracp5b诊断乳腺癌骨转移的临床价值[J].南京医科大学学报,2007,(7):702~705
血清Tracp5b诊断乳腺癌骨转移的临床价值
The clinical value of serum Tracp5b as a marker to diagnose bone metastases in breast cancer patients
投稿时间:2006-11-05  
DOI:10.7655
中文关键词: 抗酒石酸酸性磷酸酶5b  糖类抗原-153  癌胚抗原  骨转移
英文关键词: Tracp5b  CA-153  CEA  bone metastases  
基金项目:省六大人才高峰重点项目(06-B-070),省博士后基金(0601048B),江苏省卫生系统重点人才基金(135工程)
作者单位
王凤良 南京医科大学第一附属医院乳腺外科,江苏 南京 210029 
凌立君  
沈恩超  
刘晓安  
王水  
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中文摘要:
      目的:比较乳腺癌患者血清抗酒石酸酸性磷酸酶(Tracp5b)?糖类抗原-153(CA-153)及癌胚抗原(CEA)诊断乳腺癌骨转移的临床价值?方法:采用酶联免疫吸附法(ELISA)及电化学发光法检测18例健康女性?26例无骨转移的乳腺癌患者及32例乳腺癌骨转移患者的血清Tracp5b?CA-153及CEA水平?结果:乳腺癌骨转移组的血清Tracp5b水平较无骨转移组及健康对照组明显升高,差异有统计学意义(P < 0.05);血清Tracp5b诊断乳腺癌骨转移的敏感性为78.13%,特异性为86.36%;CA-153的敏感性为37.50%,特异性为77.27%;CEA的敏感性为21.88%,特异性为84.09%;Tracp5b的敏感性较CA-153?CEA高,差异有统计学意义(P < 0.05)?结论:Tracp5b可以作为诊断乳腺癌骨转移的血清标记物之一?
英文摘要:
      Objective:To compare the diagnostic value of serum tartrate-resistant acid phosphatase 5b(Tracp5b), cancer antigen 153(CA-153) and carcino embryonic antigen(CEA) in patients with bone metastases of breast cancer. Methods:The serum levels of Tracp5b, CA-153 and CEA were determined by enzyme-linked immunosorbent assay and electrochemiluminescence in 26 breast cancer patients without bone metastases, 32 breast cancer patients with bone metastases and 18 healthy female adults. Results:The serum levels of Tracp5b in breast cancer patients with bone metastases were significantly higher than those in other two groups(P < 0.05). The sensitivity and specificity of Tracp5b to bone metastases was 78.13% and 86.36%. The sensitivity and specificity of CA-153 to bone metastases was 37.50% and 77.27%, and those of CEA were 21.88% and 84.09%, respectively. The sensitivity of Tracp5b were significantly higher than those of CA-153 and CEA(P < 0.05). Conclusion:Tracp5b is a useful serum marker to diagnose bone metastases in breast cancer patients.
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