文章摘要
周肖英,孔祥清,史爱武,盛燕辉,杨荣,曹克将.左心耳封堵术前后不同时期IL-6?CRP?VWF和Ps的变化[J].南京医科大学学报,2007,(7):711~714
左心耳封堵术前后不同时期IL-6?CRP?VWF和Ps的变化
Changes of serum interleukin-6, creactive protein, von willebrand and P-selectin in pigs in different stages after left atrial appendage transcatheter occlusion
投稿时间:2007-01-23  
DOI:10.7655
中文关键词: 封堵器  IL-6  CRP  VWF  Ps
英文关键词: domestic nitinol occluder  IL-6  CRP  VWF  Ps
基金项目:
作者单位
周肖英 南京医科大学第一附属医院心血管内科,江苏 南京 210029 
孔祥清  
史爱武  
盛燕辉  
杨荣  
曹克将  
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中文摘要:
      目的:探讨经胸猪左心耳封堵术后不同时期外周血白细胞介素-6( IL-6)?C 反应蛋白(C-reactive protein,CRP)?von willebrang factor(VWF)?plasma P-selectin(Ps)的变化?方法:选用苏钟猪17只,一组12只采用开胸并经导管置入左心耳封堵器(封堵组),另一组5只仅开胸未行封堵(对照组),应用酶联免疫吸附试验(ELISA) 测定血IL-6?CRP?VWF?Ps的变化?结果:封堵组IL-6?CRP?VWF?Ps水平在术后即刻较术前增加(P < 0.05);术后1个月和3个月时的IL-6?CRP?VWF?Ps较术前比较无统计学意义(P > 0.05)?对照组术后即刻IL-6?CRP?VWF?Ps水平较术前增加(P < 0.05)?封堵组与对照组比较,术前和术后各时点IL-6?CRP?VWF?Ps水平无统计学意义(P > 0.05)?结论:IL-6?CRP?VWF?Ps水平在左心耳封堵术后有一过性增高,其炎症反应与封堵无关,而与开胸手术有关,该封堵器引起的炎症反应及血管内皮损伤较轻,生物相容性好?
英文摘要:
       Objective:To study the changes and clinical significance of serum interleukin-6(IL-6), C-reactive protein(CRP),von willebrang factor(VWF) and plasma P-selectin(Ps) in pigs in different stages after left atrial appendage transcatheter occlusion. Methods:Occlusion group with 12 shuzhong pigs and control group with 5 pigs were used in the experiment. The changes of serum IL-6,CRP,VWF and plasma Ps were measured by enzyme linked immunosorbent assay(ELISA) before the operation, immediately at the operation,and 1,3 month after the operation. Results:In occlusion group, the levels of serum IL-6,CRP,VWF and Ps were higher at immediate time after occlusion than those of before occlusion(P < 0.05), but the levels of them at 1 month and 3 month after the occlusion were as high as those of before occlusion(P > 0.05). In control group, the levels of serum IL-6,CRP,VWF and Ps were higher at immediate time after operation than those of before the left atrial appendage transcatheter occlusion(P < 0.05). There were no significant difference in the levels of serum IL-6,CRP, VWF and Ps in different stages after the operation between the occlusion group and the control group(P > 0.05). Conclusion:Levels of serum IL-6, CRP, VWF and Ps temporarily increased at immediate time after the operation. This observation showed the satisfactory biocompatibility, feasibility and safety of the domestic nitinol left atrial appendage occluder.
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