文章摘要
凌玲,孙丽洲,肖云山.子痫前期患者血清及尿液胎盘生长因子水平的变化特征[J].南京医科大学学报,2007,(7):715~717728
子痫前期患者血清及尿液胎盘生长因子水平的变化特征
Changes of serum and urinary placenta growth factor levels in preeclampsia
投稿时间:2007-01-19  
DOI:10.7655
中文关键词: 子痫前期  胎盘生长因子  尿液
英文关键词: preeclampsia  placenta growth factor  urine
基金项目:国家“十五”攻关课题(2004BA720A06-01)
作者单位
凌玲 南京医科大学第一附属医院妇产科,江苏 南京 210029 
孙丽洲  
肖云山  
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中文摘要:
      目的:研究子痫前期患者血清及尿液中胎盘生长因子水平的变化特征,并探讨血清及尿液中胎盘生长因子水平的相关性?方法:检测并比较20例轻度子痫前期患者?15例重度子痫前期患者及20例正常晚期妊娠妇女血清及尿液胎盘生长因子(placenta growth factor,PlGF)水平,并分析55例子痫前期患者及对照组孕妇血清及尿液中胎盘生长因子水平的相关性?结果:轻度子痫前期组?重度子痫前期组?对照组血清PlGF分别为(36.13 ± 17.29)?(23.40 ± 9.88)?(44.04 ± 19.26)pg/ml, 尿PlGF分别为(939.20 ± 474.94)?(587.20 ± 381.86)?(961.65 ± 584.58)pg/mmol?重度子痫前期组血清及尿液PlGF均低于正常晚期妊娠组及轻度子痫前期组PlGF平均水平,差异有显著性意义(P < 0.05);尿液PlGF水平与血清PlGF水平成正相关,相关系数为0.713(P < 0.05)?结论:重度子痫前期患者血清及尿液PlGF水平显著降低,且尿PlGF水平与血清PlGF水平成正相关,可以用尿液PlGF水平检测替代血清PlGF水平研究PlGF与子痫前期发病关系,并为子痫前期的临床监测及诊治提供更便捷的方法?
英文摘要:
       Objective:To detect the expression of placenta growth factor(PlGF) in maternal serum and urine from preeclampsia (PE), and to identify whether the level of PlGF in urine is significantly correlative with that in serum. Methods:Women enrolled prospectively in following groups: healthy pregnant control(n = 20) and PE patients, which contained mild preeclampsia(n = 20)?severe preeclampsia(n = 15). The serum and urinary PlGF levels were measured by enzyme linked immunoassay(ELISA). Results: The serum PlGF levels in severe preeclampsia group(23.40 ± 9.88)pg/ml were significantly lower than that of normal pregnancies(44.04 ± 19.26)pg/ml and mild preeclampsia group(36.13 ± 17.29)pg/ml. The urinary PlGF level in severe preeclampsia group(587.20 ± 381.86)pg/mmol was also significantly lower than that in normal pregnancies(961.65 ± 584.58)pg/mmol and mild pre-eclampsia group(939.20 ± 474.94)pg/mmol. The urinary PlGF level was significantly correlative with that in serum(r = 0.713). Conclusion:Severe preeclampsia is associated with the low serum and urinary placenta growth factor levels in late pregnancy. Urinary PlGF level is significantly correlative with serum PlGF level. The level of PlGF in urine may be used to study the connection between PE and PlGF instead of serum PlGF level and offer a more convenient method to make a diagnosis, which may guide the clinical treatment of PE.
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