文章摘要
郑金榆,张丽华,屈峰,孟奎,吴鸿雁.β-catenin在肠系膜纤维瘤病与其他胃肠道间叶性肿瘤鉴别诊断中的作用[J].南京医科大学学报,2007,(7):721~723
β-catenin在肠系膜纤维瘤病与其他胃肠道间叶性肿瘤鉴别诊断中的作用
The role of β-catenin in differential diagnosis between mesenteric fibromatosis and other mesenchymal tumors of gastrointestinal tract
投稿时间:2007-01-20  
DOI:10.7655
中文关键词: β-连环蛋白  肠系膜纤维瘤病  免疫组化  鉴别诊断
英文关键词: β-catenin  mesenteric fibromatosis  immunohistochemistry  differential diagnosis
基金项目:
作者单位
郑金榆 南京大学医学院附属鼓楼医院病理科,江苏 南京 210008 
张丽华 南京大学医学院附属鼓楼医院病理科,江苏 南京 210008 
屈峰 南京大学医学院附属鼓楼医院泌尿外科,江苏 南京 210008 
孟奎 南京大学医学院附属鼓楼医院病理科,江苏 南京 210008 
吴鸿雁 南京大学医学院附属鼓楼医院病理科,江苏 南京 210008 
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中文摘要:
      目的:探讨β-连环蛋白(β-catenin)在肠系膜纤维瘤病和其他胃肠道间叶性肿瘤鉴别诊断中的价值?方法:用免疫组化方法,研究β-catenin?vimentin?SMA?desmin?CD117?CD34?S-100在肠系膜纤维瘤病?胃肠道间质瘤(gastrointestinal stromal tumor,GIST)?平滑肌瘤?炎性肌纤维母细胞瘤及非特异性纤维组织增生中的表达?结果:5例肠系膜纤维瘤病β-catenin均为核阳性表达,其他肿瘤和瘤样病变(GIST?平滑肌瘤?炎性肌纤维母细胞瘤及非特异性增生的纤维组织)β-catenin均呈阴性表达?所有肿瘤均表达vimentin?CD117?CD34阳性表达主要见于GIST?SMA和desmin强阳性表达主要见于平滑肌瘤?S-100弱阳性表达可见于少数肠系膜纤维瘤病?GIST和平滑肌瘤?结论:β-catenin在肠系膜纤维瘤病中的表达具有较好的特异性和敏感性,β-catenin核阳性表达可望用于肠系膜纤维瘤病的诊断和鉴别诊断?
英文摘要:
       Objective:To explore the role of β-catenin in differential diagnosis between mesenteric fibromatosis and other mesenchymal tumors of gastrointestinal tract. Methods:The expressions of β-catenin, vimentin, smooth muscle actin(SMA), desmin, CD117, CD34 and S-100 in mesenteric fibromatosis, gastrointestinal stromal tumor(GIST), leiomyoma, inflammatory myofibroblastic tumor and nonspecific fibrous hyperplasia were studied by immunohistochemical method. Results:All 5 examples of mesenteric fibromatosis displayed strong nuclear β-catenin staining. All other lesions tested(GIST,leiomyoma,inflammatory myofibroblastic tumor and nonspecific fibrous hyperplasia) lacked nuclear labeling for β-catenin. All tumors showed diffuse strong positive for vimentin. The expressions of CD117 and CD34 were mainly seen in GIST. The expressions of SMA and desmin were mainly seen in leiomyoma. S-100 protein slight staining could be found in few mesenteric fibromatosis, GIST and leiomyoma. Conclusion:Nuclear β-catenin staining is specific and responsive to mesenteric fibromatosis. β-catenin could probably serve as a useful diagnostic and differential diagnostic tool of mesenteric fibromatosis.
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