文章摘要
许 虹,孙超艳,杨 佳,冯忠堂,徐国卫.拉莫三嗪?托吡酯对癫疒大鼠的脑电图及Bcl-2?Bax表达的影响[J].南京医科大学学报,2007,(8):856~859
拉莫三嗪?托吡酯对癫疒大鼠的脑电图及Bcl-2?Bax表达的影响
The effects of lamotrigine and topiramate on electroencephalogram and the expression of Bcl-2 and Bax of the epilepitic rats
投稿时间:2006-11-20  
DOI:10.7655
中文关键词: 拉莫三嗪  托吡酯  癫■  脑电图  Bcl-2  Bax
英文关键词: lamotrigine  topiramate  epilepsy  electroencephalogram  Bcl-2  Bax
基金项目:
作者单位
许 虹 昆明医学院第一附属医院神经内科,云南 昆明 650032 
孙超艳 昆明医学院第一附属医院神经内科,云南 昆明 650032 
杨 佳 昆明医学院第一附属医院神经内科,云南 昆明 650032 
冯忠堂 昆明医学院神经科学研究所,云南 昆明 650031 
徐国卫 昆明医学院第一附属医院神经内科,云南 昆明 650032 
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中文摘要:
      目的:探讨拉莫三嗪?托吡酯对青霉素致大鼠行为和脑电图的影响及其对海马神经元的保护作用?方法:观察青霉素致■组?拉莫三嗪组?托吡酯组?丙戊酸钠组大鼠■性发作,记录脑电图?免疫组化SABC染色观察Bcl-2?Bax蛋白的表达?结果:拉莫三嗪组?托吡酯组与丙戊酸钠组脑电■样放电减少,这3组比较癫■发作潜伏期和发作持续时间有统计学意义(P < 0.01)?这3组较青霉素致■组Bcl-2细胞增多,Bax细胞减少,托吡酯组?拉莫三嗪组较丙戊酸纳组Bcl-2细胞增多,以上差异均有统计学意义(P < 0.01)?结论:托吡酯?拉莫三嗪抗癫■疗效优于丙戊酸钠,且对青霉素致■大鼠模型海马神经元有保护作用?
英文摘要:
      Objective:To explore the effect of lamotrigine(LTG) and topiramate(TPM) on the behaviors and electroencephalogram (EEG) of epileptic rats induced by penicillin,and to explore the protection of LTG and TPM for the neurons of hippocampus. Methods:The seizures were observed in the group of epileptic rats induced by penicillin, the group of the rat given LTG, the group of the rat given TPM,the group of the rat given Sodium Valproate, and EEG was recorded in these groups. Immunohistochemical staining was used to observe the expression of Bcl-2 and Bax. Results:The epileptiform discharges decreased in the group of the rat given LTG and the group of the rat given Sodium Valproate, compared the group of the rat given LTG and TPM with the group of the rat given Sodium Valproate. We found that the latencies and durations of seizure between the group of the rat given LTG and the group of the rat given Sodium Valproate had significant difference(P < 0.01). Compared with the epileptic group induced by penicillin,Bcl-2 positive cells increased and Bax positive cells decreased in the group of the rat given LTG and the group of the rat given odium Valproate(P < 0.01). Compared with the group of the rat given Sodium Valproate,Bcl-2 positive cells in the group of the rats given LTG group and in the group of the rats given TPM were increased(P < 0.01). Conclusion:LTG and TPM was better than the Sodium Valproate in the anti-epileptic effects. LTG and TPM can protect hippocampal neuron in the epileptic rats induced by penicillin.
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