文章摘要
黄国荣,李相成,浦立勇,姚爱华,吕 凌,王学浩.单人操作建立大鼠原位肝移植模型的学习曲线分析[J].南京医科大学学报,2007,(9):924~926930
单人操作建立大鼠原位肝移植模型的学习曲线分析
Learning curve analysis of establishing the othotoptic liver transplantation model in rat by a single operator
投稿时间:2007-04-09  
DOI:10.7655
中文关键词: 肝移植  模型  学习曲线  大鼠
英文关键词: liver transplantation  model  learning curve  rat
基金项目:江苏省卫生厅“135工程”基金资助(135-54)
作者单位
黄国荣 南京医科大学第一附属医院肝脏外科,江苏 南京 210029 
李相成  
浦立勇  
姚爱华  
吕 凌  
王学浩  
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中文摘要:
      目的:分析单人操作大鼠原位肝移植(rat orthotopic liver transplantation,ROLT)模型建立术的学习曲线?方法: 将作者学习制作该模型最初的100例资料分为5阶段(各20例),对操作时间,无肝期,手术成功率,长期存活率及并发症率进行分析?结果:Ⅲ,Ⅳ,Ⅴ阶段操作无肝期较Ⅰ,Ⅱ阶段明显减少(P = 0.000),手术成功率从35%稳定上升至100%,长期存活率经历Ⅲ阶段55%~60%的平台期,达到95%;并发症率大大降低,模型稳定? 结论:初学者经过耐心反复的训练,可通过学习曲线,熟练掌握ROLT术,成功建立肝移植基础研究需要的各种模型?
英文摘要:
      Objective:To analyze the learning curve of establishing the model of othotoptic liver transplantation in rat by a single operator. Methods:The data of the first 100 consecutive cases of rat orthotopic liver transplantation(ROLT) model were collected for this retrospective study. The models were devided into five phages, of which each group were 20 cases. The donor and recipient operation time, anhepatic time,operation success rate,long-term survival rate and complications rate of each stage were observed and analyzed. Results:The anhepatic times of stage Ⅲ,Ⅳ and Ⅴ decreased significantly compared with the first two stages(P = 0.000). The operation success rate elevated from 35% to 100% steadily and the long-term survival rate raised to 95% with a plat-form survival rate of 55%-60% included(stageⅢ). The complications rate decreased significantly, and the ROLT model was established stably. Conclusion:Learners could grasp these skills by the learning curve with patient and training repeatedly, after which any model suitable for experimental study of liver transplantation could be established successfully.
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