文章摘要
张 丽,张颖冬,李继民,李 薇.血基质金属蛋白酶-9对恶性大脑中动脉梗死的预测意义研究[J].南京医科大学学报,2007,(9):985~988
血基质金属蛋白酶-9对恶性大脑中动脉梗死的预测意义研究
Prediction of malignant middle cerebral artery infarction by plasma MMP-9 level
投稿时间:2007-04-29  
DOI:10.7655
中文关键词: 基质金属蛋白酶-9  C反应蛋白  恶性大脑中动脉梗死
英文关键词: matrix metalloproteinase-9  C-reactive protein  malignant middle cerebral artery infarction
基金项目:
作者单位
张 丽 南京医科大学附属脑科医院老年神经科,江苏 南京 210029 
张颖冬  
李继民  
李 薇  
摘要点击次数: 1080
全文下载次数: 131
中文摘要:
      目的:探讨内皮损伤标志物基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)对急性大脑前循环区脑梗死临床进展为恶性大脑中动脉梗死(malignant middle cerebral artery infarction,m-MCA)的判定作用?方法:连续收集大脑前循环区脑梗死患者85例,其中45例进展为m-MCA?在患者入院时,以ELISA和免疫比浊法检测患者血MMP-9和C-反应蛋白(CRP)水平,并对患者临床症状及脑CT改变进行分析?结果:入院时,m-MCA患者血MMP-9水平(230.0 ± 60.5 ng/ml)明显高于非m-MCA患者(174.0 ± 56.0 ng/ml)(P < 0.001),而两组患者间血CRP水平无明显差别(8.8 ± 3.8 ng/ml vs 8.5 ± 4.0 ng/ml,P > 0.05)?血MMP-9水平≥220 ng/ml对预测m-MCA梗死有较高的敏感度(89%)?特异度(95%)?结论:血MMP-9水平增高对预测m-MCA进程有一定意义?
英文摘要:
      Objective:To evaluate the predicting value of the marker of endothelial injury:plasma matrix metalloproteinase-9(MMP-9) level on the progression of acute anterior circulating territory infarction progressing to malignant middle cerebral artery infarction(m-MCA). Methods:Eighty-five patients with acute anterior circulating territory infarction,in which 45 patients progressed to m-MCA,were collected and sampled consecutively. The plasma MMP-9 and C-reactive protein(CRP) of all patients were determined by means of ELISA and immunoturbidimetry,respectively,at admission. And the clinical characters and cranial CT features of the patients were analysed. Results:At admission,the plasma MMP-9 level in the patients with m-MCA(230.0 ± 60.5 ng/ml) was significantly higher than that in the patients with non m-MCA(174.0 ± 56.0 ng/ml)(P < 0.001),while the plasma CRP levels between m-MCA and non m-MCA patients had no significant difference(8.8 ± 3.8 ng/ml vs 8.5 ± 4.0 ng/ml,P > 0.05). The sensitivity and specificity of serum MMP-9≥220 ng/ml to predict m-MCA were 89% and 95%, respectively. Conclusion:The increased level of plasma MMP-9 may be a predictor to the m-MCA proceeding.
查看全文   查看/发表评论  下载PDF阅读器
关闭