文章摘要
王美莲,钟华绣,孙丽洲,王淑玉.两种结合雌激素对改善绝经期综合征的临床观察[J].南京医科大学学报,2007,(9):989~
两种结合雌激素对改善绝经期综合征的临床观察
Clinical observation of two kinds of conjugated estrogen in the treatment of menopausal symptoms
投稿时间:2007-04-09  
DOI:10.7655
中文关键词: 结合雌激素  倍美力  绝经期综合征
英文关键词: conjugated estrogen  Premarin  menopausal symptoms
基金项目:江苏省高校自然科学研究基金资助(05KJB320087)
作者单位
王美莲 南京医科大学第一附属医院妇产科,江苏 南京 210029 
钟华绣  
孙丽洲  
王淑玉  
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中文摘要:
      目的:观察比较结合雌激素片(试验组)与结合雌激素倍美力片(对照组)治疗绝经期综合征的疗效和安全性?方法:选取60例符合诊疗标准的患者随机分成试验组和对照组,每日服结合试验或对照药物1片, 28天为1周期,第15~28天均添加安宫黄体酮片每日4 mg,通过随机开放平行对照方法对两组潮热症状评分,Kupperman评分?血清 E2水平?血脂的变化及不良反应发生情况比较?结果:两组治疗后,潮热症状评分及Kupperman评分均明显下降,血清雌二醇?甘油三酯(TG)和高密度脂蛋白(HDL-C)均升高,低密度脂蛋白(LDL-C)降低,组内比较(P < 0.001),差异有统计学意义?组间等效性检验比较(P > 0.05),无显著性差异?不良反应两组之间比较(P > 0.05),无显著差异?结论:国产结合雌激素片和倍美力一样能有效?安全地治疗妇女绝经期综合征?
英文摘要:
      Objective:To compare the efficacy and the safety of conjugated estrogen(CE) in the treatment of menopausal with conjugated equine estrogen(Premarin). Methods:According to the standards ,a total of 60 patients were randomly divided into 2 groups:CE group and Premarin group,a period of 28 days,and from 15 to 28 days plus medroxyprogesterone(MPA) 4 mg Daily.Treatment lasted for 3 periods. This randomly publicly parallel was adopted to compare the hot flashes symptom scores,serum level of estradiol,Kupperman measurement Index and serum lipid. Results:The scores of menopausal symptom,hot flash scores and the serum level of estradiol ascent. TG?HDL-C ascented and LDL-C were reduced after treatment with CE or Premarin(P < 0.001),No significant differences were discovered between the two groups through equivalence margin(P > 0.05). There are no significant differences between the two groups on side effect(P > 0.05). Conclusion:CE is safe and effective in treatment of menopausal symptoms.
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