文章摘要
李 巍,刘 媛,黄 艳,季 勇.维拉帕米对血栓形成及血清一氧化氮水平的影响[J].南京医科大学学报,2007,(10):1080~1083
维拉帕米对血栓形成及血清一氧化氮水平的影响
Effect of verapamil on the thrombogenesis and nitric oxide level in the serum of rats
投稿时间:2007-05-16  
DOI:10.7655
中文关键词: 维拉帕米,血小板聚集率,血栓形成,一氧化氮(NO),赖氨匹林
英文关键词: verapamil  platelet aggregation  thrombogenesis  NO  Aspirin-DL-Lysin
基金项目:南京医科大学科技发展重点项目(06NMUZ006)
作者单位
李 巍 南京医科大学动脉粥样硬化研究中心,江苏 南京 210029 
刘 媛  
黄 艳  
季 勇  
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中文摘要:
      目的:探讨维拉帕米(Verapamil)对于血栓形成以及血小板聚集率的影响及其可能的机制?方法:大鼠体内分别给予不同剂量的维拉帕米(5,10,20 mg/kg)?赖氨匹林(4.5 mg/kg)以及溶剂(生理盐水2 ml)?利用大鼠颈总动脉-颈外静脉血流旁路法观察维拉帕米对血栓形成的影响,并与赖氨匹林比较;同时观察维拉帕米对于血小板聚集率的影响;提取血清,通过硝酸还原酶法测定一氧化氮(NO)代谢产物,以反映NO的水平?结果:维拉帕米可以呈浓度依赖性的降低血小板的聚集率,明显降低血栓的形成,结论:维拉帕米可能通过提高NO的水平来改善血小板的功能?
英文摘要:
      Objective:To study the effect of verapamil on platelet aggregation, thrombogenesis and the potential mechanism. Methods:The SD rats were injected the different concentration of verapamil, Aspirin-DL-Lysine and the saline solution for 7 days(i.p), respectively. After the administration, the platelet aggregation was measured by aggregometry, the thrombogenesis was tested by the pathway of arteria carotis communis-external jugular vein, and the concentration of NO was evaluated with the kit of nitrate reductase. Results:Verapamil exhibited a dose-dependent inhibitory effect on platelet aggregation and thrombus formation in rats. Conclusion: Verapamil imporoving the function of platelet was through elevating the NO level.
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