文章摘要
刘菊英,周建农,陈森清,张 彤,莫伏根,束永前.Pin1在结直肠癌中过表达及其与β-catenin关系的研究[J].南京医科大学学报,2007,(10):1138~1142
Pin1在结直肠癌中过表达及其与β-catenin关系的研究
Pin1 overexpression in colorectal cancer and its correlation with β-catenin
投稿时间:2007-01-12  
DOI:10.7655
中文关键词: Pin1  β-catenin  结直肠癌  免疫组织化学
英文关键词: Pin1  β-catenin  colorectal cancer  immunohistochemistry
基金项目:江苏省卫生厅基金重点资助(H2009)
作者单位
刘菊英 南京医科大学附属江苏省肿瘤医院肿瘤科,江苏 南京 210009 
周建农 南京医科大学附属江苏省肿瘤医院肿瘤科,江苏 南京 210009 
陈森清 南京医科大学附属江苏省肿瘤医院肿瘤科,江苏 南京 210009 
张 彤 南京医科大学附属江苏省肿瘤医院肿瘤科,江苏 南京 210009 
莫伏根 南京医科大学附属江苏省肿瘤医院肿瘤科,江苏 南京 210009 
束永前 南京医科大学第一附属医院肿瘤科,江苏 南京 210029 
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中文摘要:
      目的:探讨结直肠癌中肽基脯氨酰顺反异构酶Pin1表达与β-联蛋白(β-catenin)表达相关性及其临床意义?方法:应用免疫组化技术检测结直肠癌组织中Pin1?β-catenin表达水平,分析其相互关系及与临床病理学特征的关系,并探讨其预后价值?所有统计分析采用SPSS11.5软件包完成?结果:Pin1在36%(18/50)结直肠癌组织中过表达,β-catenin在58%(29/50)结直肠癌组织中异常蓄积,18例Pin1过表达中15例同时存在β-catenin异常蓄积,两者呈显著正相关(P = 0.006);Pin1过表达与结直肠癌病理学分级?临床分期有显著关系(P < 0.05);统计分析提示Pin1过表达与预后有显著相关性(P < 0.01),β-catenin与预后关系无显著统计学意义(P = 0.099)?结论:Pin1在结直肠癌组织中存在过表达,且与β-catenin异常蓄积正相关;Pin1与结直肠癌的预后密切相关?
英文摘要:
      Objective:To evaluate the correlation between the expression of Pin1 and β-catenin. To identify whether Pin1 was a prognostic factor in colorectal cancer. Methods:The expression of Pin1 and β-catenin proteins was detected by immunohistochemistry in 50 cases of colorectal cancer tissues. The relationships between Pin1 and β-catenin expression and clinicopathological factors were evaluated. Results:The overexpression of Pin1 and the aberrant accumulation of β-catenin in colorectal cancer was 36%(18/50) and 58%(29/50),respectively. A significant positive correlation was found between Pin1 and β-catenin(P = 0.006). The overexpression of Pin1 was related to pathological grade and tumor stage(P < 0.05). Pin1 was significantly related to the overall survival(P < 0.01). Patients with negative β-catenin expression survived longer than those with aberrant expression despite that no statistic significance was detected(P = 0.099). Conclusion:Pin1 was overexpressed and β-catenin was aberrant accumulated in colorectal cancer in this study. There was a significant correlation between their expression. Pin1 maybe a prognostic factor in colorectal cancer.
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