文章摘要
汪 雷,韦永中,孙 钰,孙思鑫.脑外伤?脊髓损伤并股骨骨折对大鼠血清Leptin的影响[J].南京医科大学学报,2007,(10):1156~1159
脑外伤?脊髓损伤并股骨骨折对大鼠血清Leptin的影响
Effect on Leptin by investigating the level of Leptin in serum of rats with brain injury and spinal injury combined femoral fracture
投稿时间:2007-04-19  
DOI:10.7655
中文关键词: Leptin  脑损伤  脊髓损伤  骨折
英文关键词: Leptin  brain injury  femoral fracture  callus formation
基金项目:江苏省卫生厅科技发展基金项目(H200512)
作者单位
汪 雷 南京医科大学第一附属医院骨科,江苏 南京 210029 
韦永中  
孙 钰  
孙思鑫  
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中文摘要:
      目的:研究大鼠脑外伤?脊髓损伤合并股骨骨折后血清Leptin水平在不同时期的变化,探讨由脑外伤及脊髓损伤合并骨折后所引起的创伤反应对Leptin的影响?方法:将72只SD大鼠随机分为对照组?骨折组?脑外伤组?脊髓损伤组?骨折合并脊髓损伤和骨折合并脑外伤组,各16只?建立大鼠中度脑损伤?脊髓损伤和骨折模型,分别于1﹑2﹑4?8﹑12 周取血清,放射免疫法测血清中Leptin水平?结果:第2,4,8周与对照组相比手术各组大鼠血清Leptin浓度均有显著性增高(P < 0.05);第4周时骨折并脑外伤组大鼠血清Leptin水平较其他手术组明显升高(P < 0.05);从第8周开始,手术各组大鼠血清Leptin浓度都有所下降,但骨折并脑外伤组Leptin浓度仍明显高于其他组(P < 0.05);第12周各组之间无统计学差异(P > 0.05)?结论: 血清Leptin水平在大鼠骨折合并脑外伤后显著升高,提示Leptin可能在骨折合并脑外伤的创伤修复中起重要作用?
英文摘要:
      Objective:To study the effect on Leptin by investigating the level of Leptin in serum of rats with brain injury and spinal injury combined femoral fracture. Methods:Seventy-two male SD rats were randomly divided into 6 groups:normal control,fracture group,brain injury group,spinal injury group,fracture with brain injury and fracture with spinal injury group(n = 16 per group). Fracture,spinal moderate injury and brain moderate injury models were established. The rats were sacrificed 2,4,8 and 12 weeks respectively after operation,and then the Leptin concentration in serum was detected by rat Leptin. Results:The serum levels of Leptin in the brain injury group,fracture group or fracture with brain injury group significantly increased as compared with that in control group at the 2nd week after operation(P < 0. 05). The concentration of the Leptin in serum of the fracture with brain injury group was higher than other operative group 4 and 8 weeks after operation(P < 0. 05); at the 12th week after operation the difference in above 6 groups was not statistically significant(P > 0. 05). Conclusion:The lever of Leptin in serum was higher in fracture with brain injury group than other groups in certain period,which suggests that Leptin probably makes a comparatively strong responsiveness to fracture with brain injury group.
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