文章摘要
李 兵,陈相健,朱舒舒,雍永宏,赵士禄,杨国平,徐晋妉,张寄南,杨 笛.芪参益气浸膏对异丙肾上腺素致大鼠慢性心力衰竭治疗作用研究[J].南京医科大学学报,2008,28(1):28~32
芪参益气浸膏对异丙肾上腺素致大鼠慢性心力衰竭治疗作用研究
The protective effects of QiShenYiQiJinGao on isoproterenol-induced heart failure in SD rats
投稿时间:2007-07-29  
DOI:10.7655
中文关键词: 慢性心力衰竭  异丙肾上腺素  芪参益气浸膏  能量代谢
英文关键词: chronic heart failure  isoproterenol  QiShenYiQiJinGao  energy metabolism
基金项目:国家自然科学基金资助(30570745);江苏省135重点实验室基金资助(SK200205)
作者单位
李 兵 南京医科大学第一附属医院心血管病研究所,江苏 南京 210029 
陈相健 南京医科大学第一附属医院心血管病研究所,江苏 南京 210029 
朱舒舒 南京医科大学第一附属医院心血管病研究所,江苏 南京 210029 
雍永宏 南京医科大学第一附属医院心血管病研究所,江苏 南京 210029 
赵士禄 南京医科大学第一附属医院心血管病研究所,江苏 南京 210029 
杨国平 南京医科大学第一附属医院心血管病研究所,江苏 南京 210029 
徐晋妉 南京医科大学第一附属医院心血管病研究所,江苏 南京 210029 
张寄南 南京医科大学第一附属医院心血管病研究所,江苏 南京 210029 
杨 笛 南京医科大学第一附属医院心血管病研究所,江苏 南京 210029 
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中文摘要:
      目的:观察芪参益气浸膏对异丙肾上腺素(ISO)诱导大鼠慢性心力衰竭(CHF)的治疗作用和对心肌能量代谢的影响 方法:142只雄性SD大鼠随机分为对照组和CHF组,模型制备采用皮下多点注射ISO法,4周后CHF组再随机分为模型组和芪参益气浸膏高?中?低3个治疗组及曲美他嗪治疗组?平均治疗5周后进行心脏超声检查,并测定心肌组织中高能磷酸化合物的含量和肌浆网Ca2+依赖型ATP酶(SERCA)活性?结果:芪参益气浸膏显著提高心衰大鼠左室短轴缩短率(FS%)(36.35 ± 3.80 vs 31.48 ± 5.98,P < 0.05),左室射血分数也有改善趋势,心肌ATP和总腺苷(TAN)含量比模型组分别提高了19%和31%,与正常对照组无统计学差异(P > 0.05)?芪参益气浸膏组和曲美他嗪组心肌SERCA活性显著高于模型组?结论:芪参益气浸膏有改善ISO诱导慢性心衰大鼠心功能的趋势,这种作用可能与心肌能量代谢的改善有关?
英文摘要:
      Objective:To investigate the protective effects of QiShenYiQiJinGao on isoproterenol-induced chronic heart failure(CHF) and its effects on the myocardial energy metabolism in SD rats. Methods:142 male SD rats were randomly divided into two groups:control group and CHF group. Rats in CHF group were injected subcutaneously with isopreteronol(ISO). Four weeks later,the rats in CHF group were randomly re-divided into five groups:CHF model group,trimetazidine treated group,QiShenYiQiJinGao high,middle and low dose group. After an average treatment for five weeks,echocardiogram was performed to assess the cardiac function changes of these rats. The myocardial high energy phosphates and sarcoplasmic reticulum Ca2+-ATPase(SERCA) activity were determined by enzymatic analyses. Results:Compare with the model group,FS was significantly increased(31.48 ± 5.98 vs 36.35 ± 3.80,P < 0.05) in QiShenYiQiJinGao group. Meanwhile,EF also had a trend to be improved in QiShenYiQiJinGao group. Furthermore,the level of ATP and TAN(TAN=ATP+ADP+AMP) was increased by 19% and 31%,which was similar to the control group(P > 0.05). Compare with the model group,the SERCA activity was significantly increased in QiShenYiQiJinGao and trimetazidine treated group. Conclusion:QiShenYiQiJinGao could improve the cardiac function of ISO-induced CHF in SD rats via enhancing myocardial energy metabolism.
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