文章摘要
季 宏,卞茸文,娄青林,仲肇舒,朱建一,解雨春.载脂蛋白E基因多态性与颈动脉粥样硬化及相关炎症因子产生的关系[J].南京医科大学学报,2008,28(1):60~63
载脂蛋白E基因多态性与颈动脉粥样硬化及相关炎症因子产生的关系
The relationship among apolipoprotein E genetic polymorphism, carotid atherosclerosis and the related inflammatory factors
投稿时间:2007-06-16  
DOI:10.7655
中文关键词: 载脂蛋白E  基因多态性  颈动脉粥样硬化  炎症因子
英文关键词: apolipoprotein E  genetic polymorphism  carotid atherosclerosis  inflammatory markers
基金项目:江苏省卫生厅重大课题项目资助(H200213)
作者单位
季 宏 江苏省老年医院心内科,江苏 南京 210024 
卞茸文 江苏省老年医院内分泌科,江苏 南京 210024 
娄青林 江苏省老年医院内分泌科,江苏 南京 210024 
仲肇舒 江苏省老年医院心内科,江苏 南京 210024 
朱建一 江苏省老年医院检验科,江苏 南京 210024 
解雨春 江苏省老年医院内分泌科,江苏 南京 210024 
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中文摘要:
      目的:探讨载脂蛋白E(ApoE)的基因多态性与颈动脉粥样硬化(CAS)及相关炎症因子产生的关系?方法:入选的83例对象均行彩色多普勒检测颈动脉内中膜厚度(IMT)及观察颈动脉有无斑块,根据结果分成CAS组及对照组,采用聚合酶链式反应-限制性片段多态性方法检测ApoE基因多态性,并测定总胆固醇(TC)?甘油三脂(TG)?高密度脂蛋白胆固醇(HDL-C)?低密度脂蛋白胆固醇(LDL-C)及相关炎症因子?结果:CAS组ε3/4基因型频率明显高于对照组(P < 0.05),两组间ε4等位基因频率差异有显著性(P < 0.05)?不同的ApoE等位基因组间TC?LDL-C?TG?颈动脉IMT?超敏C反应蛋白(Hs-CRP)和纤维蛋白原(FIB)存在显著性差异(P < 0.05),并且上述指标的值以携带ε4等位基因组为最高?结论:ApoE基因多态性是影响血清TC及LDL-C水平的重要遗传因素之一,同时与体内炎症状态相关,并且在一定程度上影响CAS病变的进程?
英文摘要:
      Objective:To explore the relationship among apolipoprotein E(ApoE) genetic polymorphism,the carotid atherosclerosis(CAS) and the produce of related inflammatory factors. Methods:Total 83 patients were examined by B-mode ultrasound to measure intima-media thickness(IMT) of the common carotid artery and plaque formation. According to the results of B-mode ultrasound examination,the patients were divided into the carotid atherosclerosis group and control group. The polymerase chain reaction restriction fragment length polymorphism technology(PCR-RFLP) was used to detect ApoE genotype; Serum triglyceride(TG),total cholesterol (TC),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C) and inflammatory factors were measured. Results:The frequency of ε3/4 in CAS group was higher than that in control group(P < O.05). The values of TC,LDL-C,TG,carotid IMT,Hs-CRP and fibrinogen among different groups of ApoE allele were significantly different(P < O.05),and the value of these parameters in the group carrying ε4 allele ranked the highest among all genetic polymorphism. Conclusion:ApoE genetic polymorphism was one of the important genetic factors affecting serum total cholesterol and LDL-C level. Meanwhile correlating with the state of inflammation in vivo,ApoE genetic polymorphism also affected CAS process in a certain extent.
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