文章摘要
许利剑,张明顺,汪宝林.复方丹参对实验性急性坏死性胰腺炎细胞因子的影响[J].南京医科大学学报,2008,28(1):71~74
复方丹参对实验性急性坏死性胰腺炎细胞因子的影响
Effects of salviamiltiorrhizabge on inflammatory cytokine in experimental acute necrotic pancreatitis in rats
投稿时间:2007-07-29  
DOI:10.7655
中文关键词: 急性坏死性胰腺炎  丹参  TNF-α  IL-1β  TGF-β
英文关键词: acute necrotic pancreatitis  salviamiltiorrhizabge  TNF-α  IL-1β  TGF-β
基金项目: 江苏省教育厅自然科学基金资助(02kjd320010)
作者单位
许利剑 南京医科大学第二附属医院腹部外科,江苏 南京 210011 
张明顺 南京医科大学微生物与免疫学系,江苏 南京 210029 
汪宝林 南京医科大学第二附属医院腹部外科,江苏 南京 210011 
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中文摘要:
      目的:探讨复方丹参对实验性急性坏死性胰腺炎(acute necrotic pancreatitis,ANP)细胞因子的影响?方法:制作ANP鼠模型,给予复方丹参治疗,制备血清,ELISA检测TNF-α?IL-1β和TGF-β的表达水平?结果:ANP模型中,TNF-α和IL-1β早期(3 h)即显著升高,TGF-β进展期(6 h)显著升高;复方丹参可以抑制炎症细胞因子TNF-α和IL-1β的分泌,抑制发病后期TGF-β的高表达?结论:复方丹参对急性坏死性胰腺炎的治疗作用可能与其抑制炎症性细胞因子TNF-α和IL-1β的分泌和影响TGF-β的产生有关?
英文摘要:
      Objective:To observe effects of salviamiltiorr hizabge on inflammatory cytokine in acute necrotic pancreatitis(ANP) in rats. Methods:The acute necrotic pancreatitis rat model was constructed while the Salviamiltiorrhizabge was administrated synchronously. ELISA was then applied to test the concentration of TNF-α and IL-1β and TGF-β in the serum. Results:On the onset of ANP(3 h),TNF-α and IL-1β were richly produced while TGF-β was obviously secreted until the 6 h after the model construction. Salviamiltiorrhizabge inhibited the production of TNF-α and IL-1β,and the expression of TGF-β at 12 h. Conclusion:Salviamiltiorrhizabge could significantly inhibit the secretion of the pro-inflammation cytokine of TNF-α and IL-1β,and the production of TGF-β. It might be involved in the therapeutic mechanism of Salviamiltiorrhizabge in acute necrotic pancreatitis in rats.
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