文章摘要
陈筱青,周晓玉.氨溴索?糖皮质激素对大鼠胎肺形态发育的影响[J].南京医科大学学报,2008,28(2):202~205
氨溴索?糖皮质激素对大鼠胎肺形态发育的影响
Effects of antenatal ambroxol and glucocorticoid on rat fetal lung morphogenesis
投稿时间:2007-09-20  
DOI:10.7655
中文关键词: 氨溴索  糖皮质激素    发育
英文关键词: ambroxol  glucocorticoid  lung  development
基金项目:
作者单位
陈筱青 南京医科大学第一附属医院河西分院,江苏 南京 210036 
周晓玉 南京医科大学附属南京儿童医院新生儿科,江苏 南京 210008 
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中文摘要:
      目的:比较产前给药氨溴索和糖皮质激素(地塞米松?倍他米松)对大鼠胎肺形态发育的影响?方法:12只孕鼠随机分成四组:生理盐水对照组,氨溴索组,地塞米松组,倍他米松组?通过光镜观察?图像分析及电镜观察比较各组孕鼠的胎仔肺组织形态发育差异?结果:光镜下各治疗组呼吸膜周径大于对照组(P < 0.05),肺泡表面积大于对照组(P < 0.01),肺泡间隔均低于对照组(P < 0.01)?倍他米松组与地塞米松组相比肺泡间隔小(P < 0.01),呼吸膜周径及肺泡表面积大(P < 0.01)?透射电镜下各治疗组肺泡Ⅱ型上皮内可见板层小体,细胞器多见,倍他米松组和地塞米松组上述改变尤为明显;而对照组内未见板层小体?细胞器少见?结论:氨溴索?地塞米松?倍他米松均能促进肺发育,且倍他米松效果优于地塞米松?氨溴索无激素用药的毒副作用,可能成为产前促进胎肺成熟的更好的选择?
英文摘要:
      Objective:To compare the effects of antenatal ambroxol and glucocorticoid(dexamethasone and betamethasone) on rat fetal lung morphogenesis. Methods:Twelve pregnant rats were randomly assigned four groups(n = 3):ambroxol group,dexamethasone group,betamethasone group and control group. The histologic structures of fetal rat lungs were observed with light microscope,transmission electron microscope and image analysis. Results:Compared with control group,fetal rat lung in the treatment groups had longer respiratory thecal perimeter(P < 0.05),larger alveolar space and thinner alveolar walls(P < 0.01). Fetal lung in the betamethasone injected rats had larger pulmonary alveoli,longer respiratory thecal perimeter and thinner alveolar septum(P < 0.01) than the dexamethasone treated animals. Under the transmission electron microscope,lamellar body and cellular organs in endochylema of typeⅡ alveolar cell of the treatment groups were more common compared with the control group. Obvious changes could be found in the fetal lung of dexamethasone and betamethasone treated animals. Conclusion:All of ambroxol,dexamethasone and betamethasone could promote the development of fetal lung,and the effect of betamethasone could be better than dexamethasone. Ambroxol could be used as an alternative drug to accelerate fetal lung maturity without the side effects of glucocorticoid.
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