文章摘要
邱 敏,龙明智,谭 晓,王迪斌.缬沙坦对心肌梗死大鼠心肌胶原重塑?ASK1的影响[J].南京医科大学学报,2008,28(5):621~624
缬沙坦对心肌梗死大鼠心肌胶原重塑?ASK1的影响
Effects of Valsartan on myocardial Collagen remodeling and ASK1 protein expression after myocardial infarction in the rat heart
投稿时间:2007-12-24  
DOI:10.7655
中文关键词: 胶原重塑  凋亡信号调节激酶1  血管紧张素Ⅱ  缬沙坦
英文关键词: collagen remodeling  ASK1  AngⅡ  Valsartan
基金项目:南京医科大学科技发展基金面上项目(06NMUM027)
作者单位
邱 敏 南京医科大学第二附属医院心内科,江苏 南京 210011 
龙明智  
谭 晓  
王迪斌  
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中文摘要:
      目的:探讨心肌梗死模型下血管紧张素Ⅱ(AngⅡ)受体拮抗剂缬沙坦对凋亡信号调节激酶1(ASK1)介导心室重塑信号通路的影响?方法:复制心肌梗死大鼠模型,苦味酸天狼猩红染色法检测心肌胶原容积分数,免疫印迹法检测心肌ASK1蛋白含量并测定大鼠血流动力学和左心室质量指数?结果:缬沙坦组左心室质量指数?胶原容积分数?ASK1表达均显著低于心肌梗死组(P < 0.05)?结论:ASK1的激活参与心肌梗死后心室重塑过程,缬沙坦能干预ASK1介导通路并改善心肌胶原重塑?
英文摘要:
      Objective:To determine the effects of Valsartan on apoptosis signal-regulating kinase 1(ASK1)-dependent signal pathway mediated myocardial remodeling after myocardial infarction in the rat heart. Methods:The myocardial infarction model was established by ligating the descending left coronary. 24 Sprague Dawley rats were randomized into three groups,myocardial infarction group,Valsartan administration group,sham-operated group. Six weeks later,Picrosirius red staining measured collagen volume fraction (CVF),ASK1 protein expression was measured by western blot,meanwhile,we measure hemodynamics and left ventricular mass index(LVMI) of rats. Results:The LVMI?CVF and ASK1 protein content all significantly decreased in Valsartan group,as compared with myocardial infarction group(P < 0.05). Conclusion:ASK1 is involved in myocardial remodeling after myocardial infarction,AngⅡcan improve myocardial Collagen remodeling by intervention ASK1-dependent signal pathway.
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