文章摘要
林丽娴,孙丽洲.Fas(TNFRSF6)基因位点A670G多态性与子痫前期的相关性研究[J].南京医科大学学报,2008,28(5):625~628
Fas(TNFRSF6)基因位点A670G多态性与子痫前期的相关性研究
A670G polymorphism at position-670 in the Fas gene in pregnant women with pre-eclampsia
投稿时间:2007-12-12  
DOI:10.7655
中文关键词: Fas  TNFRSF6  子痫前期  基因  多态性
英文关键词: Fas  TNFRSF6  pre-eclampsia  gene  polymorphism
基金项目:江苏省卫生厅医学科技发展基金(H200315)
作者单位
林丽娴 南京医科大学第一附属医院妇产科,江苏 南京 210029 
孙丽洲  
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中文摘要:
      目的:探讨Fas(TNFRSF6)基因位点A670G多态性与子痫前期(pre-eclampsia)的相关性?方法:采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法,对140例子痫前期患者(轻度子痫前期75例,重度子痫前期65例)和170例同期入院产检并在南京医科大学第一附属医院分娩的正常孕妇,进行Fas(TNFRSF6)基因位点A670G多态性的分析,比较各基因型及等位基因的频率在病例组和正常组间?轻度子痫前期组和重度子痫前期组间的差别?结果:G等位基因型频率在子痫前期组(56.4%)显著高于对照组(36.2%)(P < 0.001),G等位基因型频率在重度子痫前期组(64.6%)显著高于轻度子痫前期组(49.3%)(P = 0.010)?结论:Fas(TNFRSF6)基因位点A670G多态性的G等位基因可能是子痫前期的重要遗传危险因素,并与病情的严重程度相关?
英文摘要:
      Objective:To estimate whether A670G polymorphism at position-670 in the gene coding for Fas(gene symbol TNFRSF6) is associated with pre-eclampsia. Methods:By means of polymerase Chain Reaction and Restriction Fragment Length Polymorphism,A670G polymorphism at position -670 in the Fas(TNFRSF6) gene was detected in 140 women with pre-eclampsia(75 with mild pre-eclampsia and 65 with severe pre-eclampsia) and 170 normal control women with uncomplicated pregnancy. Investigators were blinded to clinical outcomes. Results:G Allele frequency in pre-eclampsia group were significantly higher than those in control group(56.4% vs 36.2%)(P < 0.001). G Allele frequency in severe pre-eclampsia group were significantly higher than those in mild pre-eclampsia group(64.6% vs 49.3%)(P = 0.010). Conclusion:The G Allele of Fas(TNFRSF6) gene might be a risk genetic marker of pre-eclampsia. In patients with pre-eclampsia,there is the association between G Allele of Fas(TNFRSF6) gene and severity of pre-eclampsia.
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