文章摘要
钱年凤,韩素萍,陈小军,朱 慧,王莉娜,胡志斌,沈洪兵.IL-1B及IL-1RN基因多态性与江苏地区宫颈癌遗传易感性相关[J].南京医科大学学报,2008,28(5):629~634
IL-1B及IL-1RN基因多态性与江苏地区宫颈癌遗传易感性相关
Associations between functional genetic polymorphisms of IL-1B and IL-1RN and risk of cervical cancer
  
DOI:10.7655
中文关键词: 宫颈癌  IL-1B  IL-1RN  单核苷酸多态性  分子流行病学
英文关键词: cervical cancer  IL-1B  IL-1RN  polymorphism  molecular epidemiology
基金项目:
作者单位
钱年凤 南京医科大学第一附属医院妇产科,江苏 南京 210029 
韩素萍 南京医科大学第一附属医院妇产科,江苏 南京 210029 
陈小军 南京医科大学第一附属医院妇产科,江苏 南京 210029 
朱 慧 南京医科大学第一附属医院妇产科,江苏 南京 210029 
王莉娜 南京医科大学公共卫生学院肿瘤研究中心,江苏 南京 210029 
胡志斌 南京医科大学公共卫生学院肿瘤研究中心,江苏 南京 210029 
沈洪兵 南京医科大学公共卫生学院肿瘤研究中心,江苏 南京 210029 
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中文摘要:
      目的:探讨炎症因子IL-1B(T-31C和C-511T)及其拮抗基因IL-1RN基因多态性与宫颈癌遗传易感性的关系?方法:采用病例对照研究,对经组织学确诊的宫颈癌新发病例273例按年龄和城乡频数匹配正常对照402例,以聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法进行多态性检测,比较不同基因型与宫颈癌发病风险的关系?结果:在调整年龄?城乡等因素后,携带-511CT基因型比携带CC基因型个体发生宫颈癌的危险性增加93%(调整OR=1.93,95%CI=1.00~3.72);携带-511TT基因型比携带-511CC基因型个体发生宫颈癌的危险性增加115%(调整OR=2.15,95%CI=1.02~4.53)?分层分析表明,携带IL-1B T-31C变异基因型的个体发生宫颈癌的风险仅在年龄≥50岁(调整OR=1.72,95%CI=1.01~2.93)?妊娠次数≥2次(调整OR=1.83,95%CI=1.07~3.11)和农村地区女性(调整OR=1.63,95%CI=1.04~2.54)中显著?IL-1RN各基因型在病例组和对照组中分布的差异均无统计学意义?结论:IL-1B C-511T多态性可能与江苏地区妇女的宫颈癌易感性相关?
英文摘要:
       Objective:To study the relationship between functional genetic variants of IL-1B(T-31C,C-511T) and IL-1RN genes and the susceptibility of cervical cancer. Methods:The case-control study was conducted in Jiangsu female population,including 273 cervical cancer cases and 402 cancer-free controls frequency-matched by age and residential areas. Genotypes were determined by PCR-the restriction length polymorphism(PCR-RFLP) assays. Results:The differences of IL-1B T-31C and C-511T genotype frequencies between cases and controls were not statistically significant. After adjusted age and residences,the Logistic regression analysis revealed that the increased risk of cervical cancer was associated with IL-1B -511TT and -511CT variant genotypes(OR=1.93,95% CI=1.00-3.72 for CT genotypes;OR=2.15,95%CI=1.02-4.53 for TT genotypes),compared with the -511CC genotype. Stratified analysis indicated that IL-1B T-31C variant genotypes were statistically associated with cervical cancer risk in the subjects with more than 49 years old(OR=1.72,95%CI=1.01-2.93),pregnancy frequency ≥2(OR=1.83,95%CI=1.07-3.11) and living in countryside(OR=1.63,95%CI=1.04-2.54). No significant association was observed between polymorphisms of IL-1RN gene and cervical cancer risk. Conclusion:These findings supported the hypothesis that the functional genetic variants of IL-1B C-511T might contribute to the cervical carcinogenesis in Jiangsu population.
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