文章摘要
祁永健,黄 茂.检测血浆sCD74有助于肺癌诊断[J].南京医科大学学报,2008,28(5):667~669
检测血浆sCD74有助于肺癌诊断
The significance of detecting plasm sCD74 in diagnosis of lung cancer
投稿时间:2007-11-20  
DOI:10.7655
中文关键词: 肺癌  sCD74  鳞癌
英文关键词: lung cancer  sCD74  squamous carcinoma
基金项目:
作者单位
祁永健 南京医科大学第一附属医院呼吸内科,江苏 南京 210029 
黄 茂  
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中文摘要:
      目的:探讨检测血浆游离CD74的浓度在鉴别肺癌和肺部良性疾病中的意义?方法:取肺癌患者和慢性阻塞性肺病患者的外周血5 ml,乙二胺四乙酸(ethylenediamine tetraacetic acid,EDTA)抗凝,离心取血浆-70℃保存?用双抗体夹心酶联免疫吸附测定法测定血浆中的sCD74的浓度?结果:按照病理类型实验组分为腺癌组?鳞癌组;对照组为慢性阻塞性肺病患者?腺癌组?鳞癌组?对照组的sCD7水平分别为(2.51 ± 1.36)ng/ml?(2.14 ± 1.16)ng/ml和(1.91 ± 0.78)ng/ml,腺癌患者血浆sCD74含量高于鳞癌患者和对照组?腺癌患者和鳞癌患者相比,无统计学差异(P = 0.293 > 0.05);腺癌患者与对照组相比,有统计学差异(P = 0.037 < 0.05);鳞癌患者和对照组相比,无统计学差异(P = 0.893 > 0.05)?结论:检测血浆sCD74可能有助于肺癌的诊断?
英文摘要:
      Objective:To investigate the significance of detecting plasm sCD74 in differential diagnosis of lung cancer and benign pulmonary diseases. Methods:Plasm samples were collected after centrifugation of EDTA blood specimens from patients of lung cancer and benign pulmonary diseases. The plasm level of sCD74 was identified and quantified by ELISA. Results:The concentrations of sCD74 in patients with lung squamous carcinoma,adenocarcnoma and control subjects were(2.51 ± 1.36)ng/ml,(2.14 ± 1.16)ng/ml and(1.91 ± 0.78)ng/ml. The concentrations of sCD74 in patients with lung adenocarci-noma were higher than those in the other two groups,but only significantly higher than that in control subjects(P < 0.05). Conclusion:Detecting of plasma sCD74 may play a role in diagnosis of lung adenocarcinoma.
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