文章摘要
李小琴,李 坚,陈 萍,包泉磊,杜永杰,史卫林.膜转运蛋白基因在非小细胞肺癌中的表达及预后意义[J].南京医科大学学报,2008,28(9):1150~1154
膜转运蛋白基因在非小细胞肺癌中的表达及预后意义
Expression and clinical prognostic significance of membrane transport proteins mRNA in non-small cell lung cancer
投稿时间:2008-04-19  
DOI:10.7655
中文关键词: 非小细胞肺癌  预后  MRP1  LRP  BCRP
英文关键词: non-small cell lung cancer  prognosis  MRP1  LRP  BCRP
基金项目:
作者单位
李小琴 江苏大学附属医院肿瘤科,江苏 镇江 212001 
李 坚 江苏大学附属医院呼吸内科,江苏 镇江 212001 
陈 萍 江苏大学附属医院呼吸内科,江苏 镇江 212001 
包泉磊 江苏大学附属医院呼吸内科,江苏 镇江 212001 
杜永杰 江苏大学附属医院呼吸内科,江苏 镇江 212001 
史卫林 江苏大学附属医院呼吸内科,江苏 镇江 212001 
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中文摘要:
       目的:探讨膜转运蛋白MRP1?LRP和BCRPmRNA在非小细胞肺癌(NSCLC)中的表达及临床预后意义?方法:用RT-PCR法检测60例NSCLC患者癌组织及癌旁组织中MRP1?LRP和BCRPmRNA的表达?用t检验?方差分析?秩相关分析?Kaplan-Meier生存曲线和COX多因素回归分析进行统计分析?结果:MRP1和LRPmRNA在NSCLC中的表达量高于癌旁组织(P = 0.02和P = 0.000),癌组织中两者表达呈正相关(rs = 0.530,P = 0.000),BCRPmRNA在癌组织中表达量低于癌旁组织(P = 0.042)?不同组织类型中,肺腺癌LRPmRNA表达量高于鳞癌(P = 0.02);不同临床分期癌组织中MRP1?LRP和BCRPmRNA表达均无差异?预后分析显示MRP1mRNA低表达组患者生存期明显长于高表达组(P = 0.023),MRP1mRNA高表达是影响NSCLC患者预后的独立因素?结论:MRP1?LRP和BCRPmRNA在NSCLC组织中有不同程度的表达?MRP1mRNA表达水平与患者生存期相关,可作为判断NSCLC患者预后的一项指标?
英文摘要:
      Objective:To investigate the expression levels of MRP1,LRP and BCRPmRNA in patients with non-small cell lung cancer(NSCLC) as well as their clinical prognostic significance. Methods:RT-PCR method were used to detect the expression levels of MRP1,LRP and BCRPmRNA in tissues samples and corresponding adjacent normal lung tissues of 60 patients with NSCLC. T-Test,One-Way ANOVA,rank correlation,Kaplan-Meier survival curve,and COX multivariate regression analysis were used for statistical analysis. Results:The expression levels of MRP1and LRPmRNA were higher in NSCLC tissues than that in normal lung tissues(P = 0.02 and P = 0.000). There were significant correlations between intratumoral expressions of MRP1mRNA and LRPmRNA(rs = 0.530,P = 0.000). The expression level of BCRPmRNA was lower in NSCLC tissues than that in normal lung tissues(P = 0.042).LRPmRNA expression level was higher in lung adenocarcinomas than in squamous carcinoma(P = 0.02). None of them were related to clinical TNM stage. The patients with low expression of MRP1mRNA had significantly longer survival time than those with high expression of MRP1mRNA(P = 0.023). COX multivariate regression analysis showed that expression of MRP1mRNA was an independent prognostic factor for NSCLC. Conclusion:MRP1,LRP and BCRPmRNA were expressed in various degrees in NSCLC tissues.The expression level of MRP1mRNA was related to overall survival time of NSCLC. MRP1mRNA expressions can be used as a prognostic predictor for NSCLC.
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