Objective:To prepare the hepatic-targeted Bovine serum albumin(BSA)liposome and study its physicochemical properties, to providing a new hepatic-targeted drug delivery system for protein-drug. Methods:Liposome was prepared by reverse phase evaporation method,and then the liposome was coated with O-carboxymethyl N-galactosylated chitosan(Gal-CMCS). The shape,particle size,Zeta potential,entrapment efficiency and stability were investigated. Results:Hepatic-targeted BSA liposome was round and uniform;its mean particle size was(284.1±5.41)nm;the entrapment efficiency was(34.21±1.73)%; Zeta potential was(+27.1±1.17) mV;and there was no obvious change in entrapment efficiency and particle size at 4℃ within 3 months. Conclusion:The hepatic-targeted BSA liposome was successfully prepared,with good stability and high entrapment efficiency,thus providing a new hepatic-targeted drug delivery system for protein-drug.