文章摘要
杨雪琴,陈 创,候晋轩,杨国梁,李 雁.多肿瘤标志物C12蛋白芯片对晚期胃肠癌的诊断有一定价值[J].南京医科大学学报,2008,28(10):1285~1289
多肿瘤标志物C12蛋白芯片对晚期胃肠癌的诊断有一定价值
The clinical significance of C12 multi-tumor markers protein chip diagnostic system in the diagnosis of gastrointestinal cancer
投稿时间:2008-03-25  
DOI:10.7655
中文关键词: 胃癌  结直肠癌  肿瘤标志物  临床分期  蛋白芯片
英文关键词: gastric cancer  colorectal cancer  tumor marker  clinical staging  protein biochip
基金项目:荆门市科技计划项目(08S12);教育部新世纪优秀人才支持计划(NCET-04-0669);全国优秀博士学位论文作者专项基金资助项目(200464);武汉市创新研究课题资助(20066002054)
作者单位
杨雪琴 荆楚理工学院医学院,湖北 荆门 448000 
陈 创 武汉大学中南医院肿瘤生物学行为湖北省重点实验室,湖北 武汉 430071 
候晋轩 武汉大学中南医院肿瘤生物学行为湖北省重点实验室,湖北 武汉 430071 
杨国梁 武汉大学中南医院肿瘤生物学行为湖北省重点实验室,湖北 武汉 430071 
李 雁 武汉大学中南医院肿瘤生物学行为湖北省重点实验室,湖北 武汉 430071 
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中文摘要:
      目的:探讨多肿瘤标志物C12蛋白芯片检测系统在胃肠癌的诊断价值?方法:分析总结329例胃肠癌初治患者C12芯片的检测结果,寻找出与胃肠癌相关性最强的肿瘤标志物,计算各种肿瘤标志物组合方式对提高诊断率的贡献?结果:C12系统对本组329例胃肠癌患者的总体诊断率为39.21%,Ⅰ?Ⅱ?Ⅲ?Ⅳ期患者的诊断率分别为13.73%?33.33%?38.30%?58.03%?肿瘤标志物阳性率在各临床分期中的整体差异具有统计学显著性(P < 0.01),Ⅰ期与Ⅲ期?Ⅰ期与Ⅳ期?Ⅱ期与Ⅳ期差异具有统计学显著性(P < 0.01),其余分期相比没有统计学显著性(P > 0.05)?C12系统中阳性率最高的三种TM是CEA?CA242和CA19-9,阳性率分别为27.36%?19.76%和19.45%,并且与肿瘤的分期相关?结论:C12检测系统对晚期胃肠癌的诊断有一定的价值,但对早期的敏感性不高,临床迫切需要微型高效的胃肠癌检测系统?
英文摘要:
      Objective:To assess the value of tumor markers(TMs) protein chip diagnostic system C12 in the diagnosis of gastrointestinal cancer(GIC). Methods:The sera of 329 pathologically-confirmed GIC patients were detected by the C12 protein biochip system. The most relevant TMs and the contribution of various combinations of TMs to the improvement of diagnosis were determined. Results:The diagnostic rates of C12 biochip system in 329 GIC patients were 13.73%,33.33%,38.30%,58.03% for stagesⅠ,Ⅱ,Ⅲ and Ⅳ patients,respectively,and the overall diagnostic rate was 39.21%. There were statistically significant difference(P < 0.01) among all clinical stages(contingency table chi-square test), stage Ⅰversus stage Ⅲ,stage Ⅰversus stage Ⅳ,and stage Ⅱ versus stage Ⅳ. The other comparisons didn’t have statistical significance(P > 0.05). Among all the 12 TMs,the top three positive rates of 27.36%,19.76% and 19.45% were obtained from CEA,CA242 and CA19-9,respectively,which were correlated with the stage of GIC. Conclusion:The C12 biochip diagnostic system has some value in the diagnosis of advanced GIC,but its sensitivity for early stage is poor. The miniature and effective diagnostic system is needed in clinic urgently.
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