文章摘要
丁 昊,陈宇炼.1800株结核分枝杆菌对10种抗结核药物耐药分析[J].南京医科大学学报,2008,28(10):1361~1364
1800株结核分枝杆菌对10种抗结核药物耐药分析
Surveillance of 10-drug-resistant tuberculosis in Nanjing Chest Hospital
投稿时间:2008-04-22  
DOI:10.7655
中文关键词: 结核  分枝杆菌  耐药
英文关键词: tuberculosis  Mycobacterium tuberculosis  drug resistant
基金项目:
作者单位
丁 昊 南京医科大学公共卫生学院职业医学与环境卫生学系,江苏 南京 210029 
陈宇炼  
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中文摘要:
      目的:了解住院结核患者常用10种抗结核药物的耐药趋势?方法:以南京市胸科医院2001年至2006年的培养阳性结核分枝杆菌为本次研究对象,用绝对浓度法做RFP?INH?SM?EMB?DP?OFLX?PAS?KM?TH1321和CPM10种药物的药敏试验?结果:共有耐药菌株1800例,总耐药率70%,耐多药率为54.9%?结论:结核分枝杆菌对多种药物的耐药性有差异?该院结核分枝杆菌对部分药物的耐药性流行水平有上升趋势,获得了该院耐药性水平资料,对临床用药具有重要的必要性和指导性?
英文摘要:
      Objective:To collect the data of drug resistance to evaluate the prevalence trend of 10 anti-tuberculosis drugs commonly.Methods:The study objectives were from 2001 to 2006. Susceptibility tests(absolute concentration methods for INH,SM,RFP,EMB,TH1321,PAS,AN,KM,OFLX and CPM) were done in all specimens. Results:1800 tuberculosis cases involved in the study. The culture positive rate was 70%. The rate of the tuberculosis anti-multidrugs was 54.9%. Conclusion:The rate of the tuberculosis mutidrug resistant is very different. Some of drug’s resistance trend were rising yearly. The anti-tuberculosis drug resistant surveillance were established. The reliable data on the status of anti-tuberculosis drug resistance results provided the evidences for improvement and assessment on TB control and clinical drug use.
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