Objective:To further investigate the realation between IL-10 and the pathogenesis of SLE. Methods:MDDCs was cultured with 30 pg/ml IL-10 and 0 pg/ml IL-10. The phenotypes of these DCs(CD14,CD11c,CD1a,HLA-DR,CD80,CD86 and CD83) were analyzed by flow cytometer. The stimulating allogenic lymphocytes proliferation abilities of these DCs were checked by CCK-8. ELISA was used to measure IL-12p40,IL-10 and INF-γconcentrations of the MDDCs culture supernatants. Results:The expression of HLA-DR,CD86,CD80 and CD83 of MDDCs cultured with 30 pg/ml IL-10 was lower than that of MDDCs without IL-10. MDDCs treated with 30 pg/ml IL-10 showed decreased abilities of stimulating allogenic T cells proliferation. The IL-12p40,IL-10 and INF-γconcentrations were no significant alteration. Conclusion:Exogenous IL-10 inhibited the differentiation and function of MDDCs. These results further showed that IL-10 plays an important role in the pathogenesis of SLE.